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BAC TG-EMBED: one-step method for high-level, copy-number-dependent, position-independent transgene expression
Chromosome position effects combined with transgene silencing of multi-copy plasmid insertions lead to highly variable and usually quite low expression levels of mini-genes integrated into mammalian chromosomes. Together, these effects greatly complicate obtaining high-level expression of therapeuti...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887973/ https://www.ncbi.nlm.nih.gov/pubmed/20385594 http://dx.doi.org/10.1093/nar/gkq178 |