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Proton block of the CLC-5 Cl(−)/H(+) exchanger
CLC-5 is a H(+)/Cl(−) exchanger that is expressed primarily in endosomes but can traffic to the plasma membrane in overexpression systems. Mutations altering the expression or function of CLC-5 lead to Dent’s disease. Currents mediated by this transporter show extreme outward rectification and are i...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888053/ https://www.ncbi.nlm.nih.gov/pubmed/20513761 http://dx.doi.org/10.1085/jgp.201010428 |