Cargando…
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of B-cell malignancies. Because the in vivo survival, expansion and anti-lymphoma activity of CAR.19(+) T cells remain suboptimal even when the CAR contains a CD28 costimula...
Autores principales: | Hoyos, Valentina, Savoldo, Barbara, Quintarelli, Concetta, Mahendravada, Aruna, Zhang, Ming, Vera, Juan, Heslop, Helen E, Rooney, Cliona M., Brenner, Malcolm K, Dotti, Gianpietro |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888148/ https://www.ncbi.nlm.nih.gov/pubmed/20428207 http://dx.doi.org/10.1038/leu.2010.75 |
Ejemplares similares
-
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression
por: Foster, Aaron E, et al.
Publicado: (2009) -
Selective Elimination of a Chemoresistant Side-Population of B-CLL Cells by Cytotoxic T Lymphocytes in Subjects Receiving an Autologous hCD40L/IL-2 Tumor Vaccine
por: Foster, Aaron E, et al.
Publicado: (2010) -
Safety and efficacy of targeting CD138 with a chimeric antigen receptor for the treatment of multiple myeloma
por: Sun, Chuang, et al.
Publicado: (2019) -
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes
por: Caruana, Ignazio, et al.
Publicado: (2015) -
Evidence for the Presentation of Major Histocompatibility Complex Class I–restricted Epstein-Barr Virus Nuclear Antigen 1 Peptides to CD8(+) T Lymphocytes
por: Voo, Kui Shin, et al.
Publicado: (2004)