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Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis

INTRODUCTION: The first few months after symptom onset represents a pathologically distinct phase in rheumatoid arthritis (RA). We used relevant experimental models to define the pathological role of interferon-γ (IFN-γ) during early inflammatory arthritis. METHODS: We studied IFN-γ's capacity...

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Detalles Bibliográficos
Autores principales:	Page, Charlotte E, Smale, Shaun, Carty, Sara M, Amos, Nicholas, Lauder, Sarah N, Goodfellow, Rhian M, Richards, Peter J, Jones, Simon A, Topley, Nicholas, Williams, Anwen S
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888198/ https://www.ncbi.nlm.nih.gov/pubmed/20307272 http://dx.doi.org/10.1186/ar2960

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