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B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial

INTRODUCTION: An over-expression of CD19 has been shown in B cells of systemic sclerosis (SSc) and B cells are thought to contribute to the induction of skin fibrosis in the tight skin mouse model. The aim was to define the outcome on safety and the change in skin score after rituximab therapy in SS...

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Detalles Bibliográficos
Autores principales:	Bosello, Silvia, De Santis, Maria, Lama, Gina, Spanò, Cristina, Angelucci, Cristiana, Tolusso, Barbara, Sica, Gigliola, Ferraccioli, Gianfranco
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888203/ https://www.ncbi.nlm.nih.gov/pubmed/20338043 http://dx.doi.org/10.1186/ar2965

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