Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach

Carriers of germ line mutations in breast cancer susceptibility gene BRCA1 have an increased risk of developing breast and ovarian cancers; missense mutations have, however, been difficult to assess for disease association. Here we have used a biophysical approach to classify these variants. We esta...

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Detalles Bibliográficos
Autores principales: Rowling, Pamela J. E., Cook, Rebecca, Itzhaki, Laura S.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888420/
https://www.ncbi.nlm.nih.gov/pubmed/20378548
http://dx.doi.org/10.1074/jbc.M109.088922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888420/
https://www.ncbi.nlm.nih.gov/pubmed/20378548
http://dx.doi.org/10.1074/jbc.M109.088922

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