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Toward Classification of BRCA1 Missense Variants Using a Biophysical Approach
Carriers of germ line mutations in breast cancer susceptibility gene BRCA1 have an increased risk of developing breast and ovarian cancers; missense mutations have, however, been difficult to assess for disease association. Here we have used a biophysical approach to classify these variants. We esta...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888420/ https://www.ncbi.nlm.nih.gov/pubmed/20378548 http://dx.doi.org/10.1074/jbc.M109.088922 |