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Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME

E1 ubiquitin-activating enzymes (UBAs) are large multidomain proteins that catalyze formation of a thioester bond between the terminal carboxylate of a ubiquitin or ubiquitin-like modifier (UBL) and a conserved cysteine in an E2 protein, producing reactive ubiquityl units for subsequent ligation to...

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Detalles Bibliográficos
Autores principales:	Bacik, John-Paul, Walker, John R., Ali, Mohsin, Schimmer, Aaron D., Dhe-Paganon, Sirano
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888440/ https://www.ncbi.nlm.nih.gov/pubmed/20368332 http://dx.doi.org/10.1074/jbc.M110.102921

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