Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease

Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)–New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-N...

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Autores principales: Shimizu, Chisato, Shike, Hiroko, Baker, Susan C., Garcia, Francesca, van der Hoek, Lia, Kuijpers, Taco W., Reed, Sharon L., Rowley, Anne H., Shulman, Stanford T., Talbot, Helen K. B., Williams, John V., Burns, Jane C.
Formato: Texto
Lenguaje:English
Publicado: The University of Chicago Press 2005
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888540/
https://www.ncbi.nlm.nih.gov/pubmed/16235175
http://dx.doi.org/10.1086/497170
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author Shimizu, Chisato
Shike, Hiroko
Baker, Susan C.
Garcia, Francesca
van der Hoek, Lia
Kuijpers, Taco W.
Reed, Sharon L.
Rowley, Anne H.
Shulman, Stanford T.
Talbot, Helen K. B.
Williams, John V.
Burns, Jane C.
author_facet Shimizu, Chisato
Shike, Hiroko
Baker, Susan C.
Garcia, Francesca
van der Hoek, Lia
Kuijpers, Taco W.
Reed, Sharon L.
Rowley, Anne H.
Shulman, Stanford T.
Talbot, Helen K. B.
Williams, John V.
Burns, Jane C.
author_sort Shimizu, Chisato
collection PubMed
description Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)–New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD
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spelling pubmed-28885402010-06-21 Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease Shimizu, Chisato Shike, Hiroko Baker, Susan C. Garcia, Francesca van der Hoek, Lia Kuijpers, Taco W. Reed, Sharon L. Rowley, Anne H. Shulman, Stanford T. Talbot, Helen K. B. Williams, John V. Burns, Jane C. J Infect Dis Major Articles and Brief Reports Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)–New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD The University of Chicago Press 2005-11-15 2005-11-15 /pmc/articles/PMC2888540/ /pubmed/16235175 http://dx.doi.org/10.1086/497170 Text en © 2005 by the Infectious Diseases Society of America This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Major Articles and Brief Reports
Shimizu, Chisato
Shike, Hiroko
Baker, Susan C.
Garcia, Francesca
van der Hoek, Lia
Kuijpers, Taco W.
Reed, Sharon L.
Rowley, Anne H.
Shulman, Stanford T.
Talbot, Helen K. B.
Williams, John V.
Burns, Jane C.
Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title_full Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title_fullStr Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title_full_unstemmed Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title_short Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease
title_sort human coronavirus nl63 is not detected in the respiratory tracts of children with acute kawasaki disease
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888540/
https://www.ncbi.nlm.nih.gov/pubmed/16235175
http://dx.doi.org/10.1086/497170
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