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Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia

BACKGROUND: Plasmodium vivax is responsible for a significant portion of malaria cases worldwide, especially in Asia and Latin America, where geo-helminthiasis have a high prevalence. Impact of the interaction between vivax malaria and intestinal helminthes has been poorly explored. The objective of...

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Autores principales: Melo, Gisely Cardoso, Reyes-Lecca, Roberto Carlos, Vitor-Silva, Sheila, Monteiro, Wuelton Marcelo, Martins, Marilaine, Benzecry, Silvana Gomes, Alecrim, Maria das Graças Costa, Lacerda, Marcus Vinícius Guimarães
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888569/
https://www.ncbi.nlm.nih.gov/pubmed/20574512
http://dx.doi.org/10.1371/journal.pone.0011206
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author Melo, Gisely Cardoso
Reyes-Lecca, Roberto Carlos
Vitor-Silva, Sheila
Monteiro, Wuelton Marcelo
Martins, Marilaine
Benzecry, Silvana Gomes
Alecrim, Maria das Graças Costa
Lacerda, Marcus Vinícius Guimarães
author_facet Melo, Gisely Cardoso
Reyes-Lecca, Roberto Carlos
Vitor-Silva, Sheila
Monteiro, Wuelton Marcelo
Martins, Marilaine
Benzecry, Silvana Gomes
Alecrim, Maria das Graças Costa
Lacerda, Marcus Vinícius Guimarães
author_sort Melo, Gisely Cardoso
collection PubMed
description BACKGROUND: Plasmodium vivax is responsible for a significant portion of malaria cases worldwide, especially in Asia and Latin America, where geo-helminthiasis have a high prevalence. Impact of the interaction between vivax malaria and intestinal helminthes has been poorly explored. The objective of this study was to evaluate the influence of intestinal helminthiasis on the concentration of hemoglobin in children with Plasmodium vivax malaria in rural areas in the municipality of Careiro, in the Western Brazilian Amazon. METHODOLOGY/PRINCIPAL FINDINGS: A cohort study was conducted from April to November 2008, enrolling children from 5 to 14 years old in two rural areas endemic for malaria. A cross-sectional evaluation was performed in April to actively detect cases of malaria and document baseline hemoglobin and nutritional status. Children were followed-up for six months through passive case detection of malaria based on light microscopy. Throughout the follow-up interval, hemoglobin value and stool examination (three samples on alternate days) were performed on children who developed P. vivax malaria. For 54 schoolchildren with a single infection by P. vivax, hemoglobin during the malaria episode was similar to the baseline hemoglobin for children co-infected with Ascaris lumbricoides (n = 18), hookworm (n = 11) and Trichuris trichiura (n = 9). In children without intestinal helminthes, a significant decrease in the hemoglobin during the malarial attack was seen as compared to the baseline concentration. In the survival analysis, no difference was seen in the time (in days) from the baseline cross-sectional to the first malarial infection, between parasitized and non-parasitized children. CONCLUSION/SIGNIFICANCE: For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax.
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spelling pubmed-28885692010-06-23 Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia Melo, Gisely Cardoso Reyes-Lecca, Roberto Carlos Vitor-Silva, Sheila Monteiro, Wuelton Marcelo Martins, Marilaine Benzecry, Silvana Gomes Alecrim, Maria das Graças Costa Lacerda, Marcus Vinícius Guimarães PLoS One Research Article BACKGROUND: Plasmodium vivax is responsible for a significant portion of malaria cases worldwide, especially in Asia and Latin America, where geo-helminthiasis have a high prevalence. Impact of the interaction between vivax malaria and intestinal helminthes has been poorly explored. The objective of this study was to evaluate the influence of intestinal helminthiasis on the concentration of hemoglobin in children with Plasmodium vivax malaria in rural areas in the municipality of Careiro, in the Western Brazilian Amazon. METHODOLOGY/PRINCIPAL FINDINGS: A cohort study was conducted from April to November 2008, enrolling children from 5 to 14 years old in two rural areas endemic for malaria. A cross-sectional evaluation was performed in April to actively detect cases of malaria and document baseline hemoglobin and nutritional status. Children were followed-up for six months through passive case detection of malaria based on light microscopy. Throughout the follow-up interval, hemoglobin value and stool examination (three samples on alternate days) were performed on children who developed P. vivax malaria. For 54 schoolchildren with a single infection by P. vivax, hemoglobin during the malaria episode was similar to the baseline hemoglobin for children co-infected with Ascaris lumbricoides (n = 18), hookworm (n = 11) and Trichuris trichiura (n = 9). In children without intestinal helminthes, a significant decrease in the hemoglobin during the malarial attack was seen as compared to the baseline concentration. In the survival analysis, no difference was seen in the time (in days) from the baseline cross-sectional to the first malarial infection, between parasitized and non-parasitized children. CONCLUSION/SIGNIFICANCE: For the first time, a cohort study showed that intestinal helminthes protect against hemoglobin decrease during an acute malarial attack by P. vivax. Public Library of Science 2010-06-21 /pmc/articles/PMC2888569/ /pubmed/20574512 http://dx.doi.org/10.1371/journal.pone.0011206 Text en Melo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Melo, Gisely Cardoso
Reyes-Lecca, Roberto Carlos
Vitor-Silva, Sheila
Monteiro, Wuelton Marcelo
Martins, Marilaine
Benzecry, Silvana Gomes
Alecrim, Maria das Graças Costa
Lacerda, Marcus Vinícius Guimarães
Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title_full Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title_fullStr Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title_full_unstemmed Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title_short Concurrent Helminthic Infection Protects Schoolchildren with Plasmodium vivax from Anemia
title_sort concurrent helminthic infection protects schoolchildren with plasmodium vivax from anemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888569/
https://www.ncbi.nlm.nih.gov/pubmed/20574512
http://dx.doi.org/10.1371/journal.pone.0011206
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