Cargando…
Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
The inhibition of specific SH2 domain mediated protein-protein interactions as an effective chemotherapeutic approach in the treatment of diseases remains a challenge. That different conformations of peptide-ligands are preferred by different SH2 domains is an underappreciated observation from the s...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888578/ https://www.ncbi.nlm.nih.gov/pubmed/20574521 http://dx.doi.org/10.1371/journal.pone.0011215 |