Cargando…

Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the mdx Mouse Model of Duchenne Muscular Dystrophy

BACKGROUND: The number of promising therapeutic interventions for Duchenne Muscular Dystrophy (DMD) is increasing rapidly. One of the proposed strategies is to use drugs that are known to act by multiple different mechanisms including inducing of homologous fetal form of adult genes, for example utr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerron, Alfredo D., Rawat, Rashmi, Sali, Arpana, Spurney, Christopher F., Pistilli, Emidio, Cha, Hee-Jae, Pandey, Gouri S., Gernapudi, Ramkishore, Francia, Dwight, Farajian, Viken, Escolar, Diana M., Bossi, Laura, Becker, Magali, Zerr, Patricia, de la Porte, Sabine, Gordish-Dressman, Heather, Partridge, Terence, Hoffman, Eric P., Nagaraju, Kanneboyina
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888587/ https://www.ncbi.nlm.nih.gov/pubmed/20574530 http://dx.doi.org/10.1371/journal.pone.0011220

Ejemplares similares

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Glucocorticoid-Treated Mice Are an Inappropriate Positive Control for Long-Term Preclinical Studies in the mdx Mouse
por: Sali, Arpana, et al.
Publicado: (2012)

Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse
por: Spurney, Christopher F., et al.
Publicado: (2010)

The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice
por: Sali, Arpana, et al.
Publicado: (2013)

IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
por: Kostek, Matthew C, et al.
Publicado: (2012)

Non-Invasive MRI and Spectroscopy of mdx Mice Reveal Temporal Changes in Dystrophic Muscle Imaging and in Energy Deficits
por: Heier, Christopher R., et al.
Publicado: (2014)

Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia
por: Duddy, William, et al.
Publicado: (2015)

Effect of the IL-1 Receptor Antagonist Kineret(®) on Disease Phenotype in mdx Mice
por: Benny Klimek, Margaret E., et al.
Publicado: (2016)

Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice
por: Spurney, Christopher F, et al.
Publicado: (2011)

Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
por: Ziemba, Michael, et al.
Publicado: (2021)

Omigapil Treatment Decreases Fibrosis and Improves Respiratory Rate in dy(2J) Mouse Model of Congenital Muscular Dystrophy
por: Yu, Qing, et al.
Publicado: (2013)

Non-invasive Optical Imaging of Muscle Pathology in mdx Mice Using Cathepsin Caged Near-Infrared Imaging
por: Baudy, Andreas R., et al.
Publicado: (2010)

“Of Mice and Measures”: A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic: First Workshop Report: Examining current findings and opportunities around the emerging D2.B10-Dmd(mdx)/J (D2/mdx) model in context of the classic C57BL/10ScSn-Dmd(mdx)/J (Bl10/mdx)
por: Gordish-Dressman, Heather, et al.
Publicado: (2018)

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
por: Tatem, Kathleen S., et al.
Publicado: (2014)

Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model
por: Jahnke, Vanessa E, et al.
Publicado: (2012)

Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
por: Tawalbeh, Shefa, et al.
Publicado: (2020)

Characterization of Dysferlin Deficient SJL/J Mice to Assess Preclinical Drug Efficacy: Fasudil Exacerbates Muscle Disease Phenotype
por: Rayavarapu, Sree, et al.
Publicado: (2010)

Muscle miRNAome shows suppression of chronic inflammatory miRNAs with both prednisone and vamorolone
por: Fiorillo, Alyson A., et al.
Publicado: (2018)

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne
por: Thangarajh, Mathula, et al.
Publicado: (2019)

Long-Term Efficacy of Systemic Multiexon Skipping Targeting Dystrophin Exons 45–55 With a Cocktail of Vivo-Morpholinos in Mdx52 Mice
por: Echigoya, Yusuke, et al.
Publicado: (2015)

Characterization of CADD522, a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity
por: Kim, Myoung Sook, et al.
Publicado: (2017)

Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes
por: Hoffman, Eric P., et al.
Publicado: (2018)

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse
por: Zhang, Aiping, et al.
Publicado: (2015)

Characterization of the CD49f(+)/CD44(+)/CD24(−) single-cell derived stem cell population in basal-like DCIS cells
por: Duru, Nadire, et al.
Publicado: (2016)

Loss of miR-140 is a key risk factor for radiation-induced lung fibrosis through reprogramming fibroblasts and macrophages
por: Duru, Nadire, et al.
Publicado: (2016)

Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis
por: Lo, Pang-Kuo, et al.
Publicado: (2016)

Greater Colo-Rectal Activation Phenotype in Exercised mdx Mice
por: Nearing, Marie, et al.
Publicado: (2018)

Neurodevelopmental Needs in Young Boys with Duchenne Muscular Dystrophy (DMD): Observations from the Cooperative International Neuromuscular Research Group (CINRG) DMD Natural History Study (DNHS).
por: Thangarajh, Mathula, et al.
Publicado: (2018)

Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy
por: Wuebbles, Ryan D., et al.
Publicado: (2013)

Effect of TNF-α on human ARPE-19-secreted proteins
por: An, Eunkyung, et al.
Publicado: (2008)

Effect of endurance exercise on microRNAs in myositis skeletal muscle—A randomized controlled study
por: Boehler, Jessica F., et al.
Publicado: (2017)

Effects of Dantrolene Therapy on Disease Phenotype in Dystrophin Deficient mdx Mice
por: Quinn, James L, et al.
Publicado: (2013)

Skeletal, cardiac, and respiratory muscle function and histopathology in the P448Lneo− mouse model of FKRP-deficient muscular dystrophy
por: Yu, Qing, et al.
Publicado: (2018)

Speckle tracking analysis of the left ventricular anterior wall shows significantly decreased relative radial strain patterns in dystrophin deficient mice after 9 months of age
por: Spurney, Christopher, et al.
Publicado: (2012)

Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy
por: Willmann, Raffaella, et al.
Publicado: (2017)

Fast Track to MDX
por: Whitehorn, Mark, et al.
Publicado: (2005)

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis
por: Kim, Myoung Sook, et al.
Publicado: (2020)

VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects
por: Heier, Christopher R, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_oip3fr9g4sfa298kn54rbbffrh