Prostaglandin (PG)D(2) and 15-deoxy-Δ(12),(14)-PGJ(2), but not PGE(2), Mediate Shear-Induced Chondrocyte Apoptosis via Protein Kinase A-dependent Regulation of Polo-like Kinases

Excessive mechanical loading of cartilage producing hydrostatic stress, tensile strain and fluid flow leads to chondrocyte apoptosis and osteoarthritis. High fluid flow induces cyclooxygenase-2 (COX-2) expression in sheared chondrocytes, which suppresses their antioxidant capacity and contributes to...

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Detalles Bibliográficos
Autores principales: Zhu, Fei, Wang, Pu, Kontrogianni-Konstantopoulos, Aikaterini, Konstantopoulos, Konstantinos
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888831/
https://www.ncbi.nlm.nih.gov/pubmed/20150912
http://dx.doi.org/10.1038/cdd.2010.13

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