Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase

[Image: see text] Undecaprenyl pyrophosphate synthase (UPPS) catalyzes the consecutive condensation of eight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to generate the C(55) undecaprenyl pyrophosphate (UPP). It has been demonstrated that tetramic acids (TAs) are s...

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Detalles Bibliográficos
Autores principales: Lee, Lac V., Granda, Brian, Dean, Karl, Tao, Jianshi, Liu, Eugene, Zhang, Rui, Peukert, Stefan, Wattanasin, Sompong, Xie, Xiaoling, Ryder, Neil S., Tommasi, Ruben, Deng, Gejing
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889672/
https://www.ncbi.nlm.nih.gov/pubmed/20476728
http://dx.doi.org/10.1021/bi100523c

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