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Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging
Ex vivo magnetic resonance imaging yields high resolution images that reveal detailed cerebral anatomy and explicit cytoarchitecture in the cerebral cortex, subcortical structures, and white matter in the human brain. Our data illustrate neuroanatomical correlates of limbic circuitry with high resol...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889718/ https://www.ncbi.nlm.nih.gov/pubmed/20577631 http://dx.doi.org/10.3389/fnhum.2010.00042 |
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author | Augustinack, Jean C. Helmer, Karl Huber, Kristen E. Kakunoori, Sita Zöllei, Lilla Fischl, Bruce |
author_facet | Augustinack, Jean C. Helmer, Karl Huber, Kristen E. Kakunoori, Sita Zöllei, Lilla Fischl, Bruce |
author_sort | Augustinack, Jean C. |
collection | PubMed |
description | Ex vivo magnetic resonance imaging yields high resolution images that reveal detailed cerebral anatomy and explicit cytoarchitecture in the cerebral cortex, subcortical structures, and white matter in the human brain. Our data illustrate neuroanatomical correlates of limbic circuitry with high resolution images at high field. In this report, we have studied ex vivo medial temporal lobe samples in high resolution structural MRI and high resolution diffusion MRI. Structural and diffusion MRIs were registered to each other and to histological sections stained for myelin for validation of the perforant pathway. We demonstrate probability maps and fiber tracking from diffusion tensor data that allows the direct visualization of the perforant pathway. Although it is not possible to validate the DTI data with invasive measures, results described here provide an additional line of evidence of the perforant pathway trajectory in the human brain and that the perforant pathway may cross the hippocampal sulcus. |
format | Text |
id | pubmed-2889718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28897182010-06-24 Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging Augustinack, Jean C. Helmer, Karl Huber, Kristen E. Kakunoori, Sita Zöllei, Lilla Fischl, Bruce Front Hum Neurosci Neuroscience Ex vivo magnetic resonance imaging yields high resolution images that reveal detailed cerebral anatomy and explicit cytoarchitecture in the cerebral cortex, subcortical structures, and white matter in the human brain. Our data illustrate neuroanatomical correlates of limbic circuitry with high resolution images at high field. In this report, we have studied ex vivo medial temporal lobe samples in high resolution structural MRI and high resolution diffusion MRI. Structural and diffusion MRIs were registered to each other and to histological sections stained for myelin for validation of the perforant pathway. We demonstrate probability maps and fiber tracking from diffusion tensor data that allows the direct visualization of the perforant pathway. Although it is not possible to validate the DTI data with invasive measures, results described here provide an additional line of evidence of the perforant pathway trajectory in the human brain and that the perforant pathway may cross the hippocampal sulcus. Frontiers Research Foundation 2010-05-28 /pmc/articles/PMC2889718/ /pubmed/20577631 http://dx.doi.org/10.3389/fnhum.2010.00042 Text en Copyright © 2010 Augustinack, Helmer, Huber, Kakunoori, Zöllei and Fischl. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Augustinack, Jean C. Helmer, Karl Huber, Kristen E. Kakunoori, Sita Zöllei, Lilla Fischl, Bruce Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title | Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title_full | Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title_fullStr | Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title_full_unstemmed | Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title_short | Direct Visualization of the Perforant Pathway in the Human Brain with Ex Vivo Diffusion Tensor Imaging |
title_sort | direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889718/ https://www.ncbi.nlm.nih.gov/pubmed/20577631 http://dx.doi.org/10.3389/fnhum.2010.00042 |
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