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Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

OBJECTIVE: The sodium-calcium exchanger isoform 1 (NCX1) regulates cytoplasmic calcium (Ca(2+)(c)) required for insulin secretion in β-cells. NCX1 is alternatively spliced, resulting in the expression of splice variants in different tissues such as NCX1.3 and -1.7 in β-cells. As pharmacological inhi...

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Detalles Bibliográficos
Autores principales:	Hamming, Kevin S.C., Soliman, Daniel, Webster, Nicola J., Searle, Gavin J., Matemisz, Laura C., Liknes, David A., Dai, Xiao-Qing, Pulinilkunnil, Thomas, Riedel, Michael J., Dyck, Jason R.B., MacDonald, Patrick E., Light, Peter E.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889768/ https://www.ncbi.nlm.nih.gov/pubmed/20413506 http://dx.doi.org/10.2337/db09-0630

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