Sitagliptin (MK0431) Inhibition of Dipeptidyl Peptidase IV Decreases Nonobese Diabetic Mouse CD4(+) T-Cell Migration Through Incretin-Dependent and -Independent Pathways

OBJECTIVE: Treatment of NOD mice with the dipeptidyl peptidase-IV (DPP-IV) inhibitor sitagliptin preserved islet transplants through a pathway involving modulation of splenic CD4(+) T-cell migration. In the current study, effects of sitagliptin on migration of additional subsets of CD4(+) T-cells we...

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Detalles Bibliográficos
Autores principales: Kim, Su-Jin, Nian, Cuilan, McIntosh, Christopher H.S.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889774/
https://www.ncbi.nlm.nih.gov/pubmed/20368408
http://dx.doi.org/10.2337/db09-1618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889774/
https://www.ncbi.nlm.nih.gov/pubmed/20368408
http://dx.doi.org/10.2337/db09-1618

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