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Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

Viral fusogenic envelope proteins are important targets for the development of inhibitors of viral entry. We report an approach for the computational design of peptide inhibitors of the dengue 2 virus (DENV-2) envelope (E) protein using high-resolution structural data from a pre-entry dimeric form o...

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Detalles Bibliográficos
Autores principales:	Costin, Joshua M., Jenwitheesuk, Ekachai, Lok, Shee-Mei, Hunsperger, Elizabeth, Conrads, Kelly A., Fontaine, Krystal A., Rees, Craig R., Rossmann, Michael G., Isern, Sharon, Samudrala, Ram, Michael, Scott F.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889824/ https://www.ncbi.nlm.nih.gov/pubmed/20582308 http://dx.doi.org/10.1371/journal.pntd.0000721

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