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Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort
BACKGROUND: The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMD(a)) in a primary care based cohort of women with inflammatory polyarthritis. METHODS: Women aged 16 years and over with recent onset inflammatory polyart...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889849/ https://www.ncbi.nlm.nih.gov/pubmed/20509941 http://dx.doi.org/10.1186/1471-2474-11-106 |
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author | Pye, Stephen R Marshall, Tarnya Gaffney, Karl Silman, Alan J Symmons, Deborah PM O'Neill, Terence W |
author_facet | Pye, Stephen R Marshall, Tarnya Gaffney, Karl Silman, Alan J Symmons, Deborah PM O'Neill, Terence W |
author_sort | Pye, Stephen R |
collection | PubMed |
description | BACKGROUND: The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMD(a)) in a primary care based cohort of women with inflammatory polyarthritis. METHODS: Women aged 16 years and over with recent onset inflammatory polyarthritis were recruited to the Norfolk Arthritis Register (NOAR) between 1990 and 1993. Subjects were examined at both baseline and follow up for the presence of tender, swollen and deformed joints. At the 10(th )anniversary visit, a sub-sample of women were invited to complete a bone health questionnaire and attend for BMD(a )(Hologic, QDR 4000). Linear regression was used to examine the association between BMD(a )with both (i) arthritis-related factors assessed at baseline and the 10(th )anniversary visit and (ii) standard risk factors for osteoporosis. Adjustments were made for age. RESULTS: 108 women, mean age 58.0 years were studied. Older age, decreasing weight and BMI at follow up were all associated with lower BMD(a )at both the spine and femoral neck. None of the lifestyle factors were linked. Indices of joint damage including 10(th )anniversary deformed joint count and erosive joint count were the arthritis-related variables linked with a reduction in BMD(a )at the femoral neck. By contrast, disease activity as determined by the number of tender and or swollen joints assessed both at baseline and follow up was not linked with BMD(a )at either site. CONCLUSION: Cumulative disease damage was the strongest predictor of reduced femoral bone density. Other disease and lifestyle factors have only a modest influence. |
format | Text |
id | pubmed-2889849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28898492010-06-23 Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort Pye, Stephen R Marshall, Tarnya Gaffney, Karl Silman, Alan J Symmons, Deborah PM O'Neill, Terence W BMC Musculoskelet Disord Research article BACKGROUND: The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMD(a)) in a primary care based cohort of women with inflammatory polyarthritis. METHODS: Women aged 16 years and over with recent onset inflammatory polyarthritis were recruited to the Norfolk Arthritis Register (NOAR) between 1990 and 1993. Subjects were examined at both baseline and follow up for the presence of tender, swollen and deformed joints. At the 10(th )anniversary visit, a sub-sample of women were invited to complete a bone health questionnaire and attend for BMD(a )(Hologic, QDR 4000). Linear regression was used to examine the association between BMD(a )with both (i) arthritis-related factors assessed at baseline and the 10(th )anniversary visit and (ii) standard risk factors for osteoporosis. Adjustments were made for age. RESULTS: 108 women, mean age 58.0 years were studied. Older age, decreasing weight and BMI at follow up were all associated with lower BMD(a )at both the spine and femoral neck. None of the lifestyle factors were linked. Indices of joint damage including 10(th )anniversary deformed joint count and erosive joint count were the arthritis-related variables linked with a reduction in BMD(a )at the femoral neck. By contrast, disease activity as determined by the number of tender and or swollen joints assessed both at baseline and follow up was not linked with BMD(a )at either site. CONCLUSION: Cumulative disease damage was the strongest predictor of reduced femoral bone density. Other disease and lifestyle factors have only a modest influence. BioMed Central 2010-05-28 /pmc/articles/PMC2889849/ /pubmed/20509941 http://dx.doi.org/10.1186/1471-2474-11-106 Text en Copyright ©2010 Pye et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research article Pye, Stephen R Marshall, Tarnya Gaffney, Karl Silman, Alan J Symmons, Deborah PM O'Neill, Terence W Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title | Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title_full | Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title_fullStr | Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title_full_unstemmed | Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title_short | Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMD(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
title_sort | influence of arthritis and non-arthritis related factors on areal bone mineral density (bmd(a)) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort |
topic | Research article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889849/ https://www.ncbi.nlm.nih.gov/pubmed/20509941 http://dx.doi.org/10.1186/1471-2474-11-106 |
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