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K(+ )channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
BACKGROUND: Lung epithelial Na(+ )channels (ENaC) are regulated by cell Ca(2+ )signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K(+ )channel modulators regulate ENaC activity in normal lungs, the therapeutical relevance and the underlying mechanisms have...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889873/ https://www.ncbi.nlm.nih.gov/pubmed/20507598 http://dx.doi.org/10.1186/1465-9921-11-65 |