The architecture of RNA polymerase fidelity

The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the wa...

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Detalles Bibliográficos
Autor principal: Kaplan, Craig D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Focus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889878/
https://www.ncbi.nlm.nih.gov/pubmed/20598112
http://dx.doi.org/10.1186/1741-7007-8-85
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author Kaplan, Craig D
author_facet Kaplan, Craig D
author_sort Kaplan, Craig D
collection PubMed
description The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates. See research article http://www.biomedcentral.com/1741-7007/8/54
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spelling pubmed-28898782010-06-23 The architecture of RNA polymerase fidelity Kaplan, Craig D BMC Biol Focus The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates. See research article http://www.biomedcentral.com/1741-7007/8/54 BioMed Central 2010-06-22 /pmc/articles/PMC2889878/ /pubmed/20598112 http://dx.doi.org/10.1186/1741-7007-8-85 Text en Copyright ©2010 Kaplan; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Focus
Kaplan, Craig D
The architecture of RNA polymerase fidelity
title The architecture of RNA polymerase fidelity
title_full The architecture of RNA polymerase fidelity
title_fullStr The architecture of RNA polymerase fidelity
title_full_unstemmed The architecture of RNA polymerase fidelity
title_short The architecture of RNA polymerase fidelity
title_sort architecture of rna polymerase fidelity
topic Focus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889878/
https://www.ncbi.nlm.nih.gov/pubmed/20598112
http://dx.doi.org/10.1186/1741-7007-8-85
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