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Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour

BACKGROUND: Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odours of mammals provide a broad range of information about the individual owner an...

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Autores principales: Roberts, Sarah A, Simpson, Deborah M, Armstrong, Stuart D, Davidson, Amanda J, Robertson, Duncan H, McLean, Lynn, Beynon, Robert J, Hurst, Jane L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890510/
https://www.ncbi.nlm.nih.gov/pubmed/20525243
http://dx.doi.org/10.1186/1741-7007-8-75
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author Roberts, Sarah A
Simpson, Deborah M
Armstrong, Stuart D
Davidson, Amanda J
Robertson, Duncan H
McLean, Lynn
Beynon, Robert J
Hurst, Jane L
author_facet Roberts, Sarah A
Simpson, Deborah M
Armstrong, Stuart D
Davidson, Amanda J
Robertson, Duncan H
McLean, Lynn
Beynon, Robert J
Hurst, Jane L
author_sort Roberts, Sarah A
collection PubMed
description BACKGROUND: Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odours of mammals provide a broad range of information about the individual owner and stimulate individual-specific responses that are modulated by learning. How do mammals use such odours to coordinate important social interactions such as sexual attraction while allowing for individual-specific choice? We hypothesized that male mouse urine contains a specific pheromonal component that invokes inherent sexual attraction to the scent and which also stimulates female memory and conditions sexual attraction to the airborne odours of an individual scent owner associated with this pheromone. RESULTS: Using wild-stock house mice to ensure natural responses that generalize across individual genomes, we identify a single atypical male-specific major urinary protein (MUP) of mass 18893Da that invokes a female's inherent sexual attraction to male compared to female urinary scent. Attraction to this protein pheromone, which we named darcin, was as strong as the attraction to intact male urine. Importantly, contact with darcin also stimulated a strong learned attraction to the associated airborne urinary odour of an individual male, such that, subsequently, females were attracted to the airborne scent of that specific individual but not to that of other males. CONCLUSIONS: This involatile protein is a mammalian male sex pheromone that stimulates a flexible response to individual-specific odours through associative learning and memory, allowing female sexual attraction to be inherent but selective towards particular males. This 'darcin effect' offers a new system to investigate the neural basis of individual-specific memories in the brain and give new insights into the regulation of behaviour in complex social mammals. See associated Commentary http://www.biomedcentral.com/1741-7007/8/71
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spelling pubmed-28905102010-06-24 Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour Roberts, Sarah A Simpson, Deborah M Armstrong, Stuart D Davidson, Amanda J Robertson, Duncan H McLean, Lynn Beynon, Robert J Hurst, Jane L BMC Biol Research article BACKGROUND: Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odours of mammals provide a broad range of information about the individual owner and stimulate individual-specific responses that are modulated by learning. How do mammals use such odours to coordinate important social interactions such as sexual attraction while allowing for individual-specific choice? We hypothesized that male mouse urine contains a specific pheromonal component that invokes inherent sexual attraction to the scent and which also stimulates female memory and conditions sexual attraction to the airborne odours of an individual scent owner associated with this pheromone. RESULTS: Using wild-stock house mice to ensure natural responses that generalize across individual genomes, we identify a single atypical male-specific major urinary protein (MUP) of mass 18893Da that invokes a female's inherent sexual attraction to male compared to female urinary scent. Attraction to this protein pheromone, which we named darcin, was as strong as the attraction to intact male urine. Importantly, contact with darcin also stimulated a strong learned attraction to the associated airborne urinary odour of an individual male, such that, subsequently, females were attracted to the airborne scent of that specific individual but not to that of other males. CONCLUSIONS: This involatile protein is a mammalian male sex pheromone that stimulates a flexible response to individual-specific odours through associative learning and memory, allowing female sexual attraction to be inherent but selective towards particular males. This 'darcin effect' offers a new system to investigate the neural basis of individual-specific memories in the brain and give new insights into the regulation of behaviour in complex social mammals. See associated Commentary http://www.biomedcentral.com/1741-7007/8/71 BioMed Central 2010-06-03 /pmc/articles/PMC2890510/ /pubmed/20525243 http://dx.doi.org/10.1186/1741-7007-8-75 Text en Copyright ©2010 Roberts et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Roberts, Sarah A
Simpson, Deborah M
Armstrong, Stuart D
Davidson, Amanda J
Robertson, Duncan H
McLean, Lynn
Beynon, Robert J
Hurst, Jane L
Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title_full Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title_fullStr Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title_full_unstemmed Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title_short Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
title_sort darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890510/
https://www.ncbi.nlm.nih.gov/pubmed/20525243
http://dx.doi.org/10.1186/1741-7007-8-75
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