Sodium 4-phenylbutyrate ameliorates the effects of cataract-causing mutant gammaD-crystallin in cultured cells

PURPOSE: gammaD-Crystallin (CRYGD) is a major structural lens crystallin and its mutations result in congenital cataract formation. In this study, we attempted to correct the altered protein features of G165fsX8 CRYGD protein with small chemical molecules. METHODS: Recombinant FLAG-tagged mutants (R...

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Detalles Bibliográficos
Autores principales: Gong, Bo, Zhang, Li-Yun, Lam, Dennis Shun-Chiu, Pang, Chi-Pui, Yam, Gary Hin-Fai
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890554/
https://www.ncbi.nlm.nih.gov/pubmed/20577655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890554/
https://www.ncbi.nlm.nih.gov/pubmed/20577655

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