Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling

BACKGROUND: In periaqueductal grey (PAG) matter, cross-talk between the Mu-opioid receptor (MOR) and the glutamate N-methyl-D-Aspartate receptor (NMDAR)-CaMKII pathway supports the development of analgesic tolerance to morphine. In neurons, histidine triad nucleotide binding protein 1 (HINT1) connec...

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Detalles Bibliográficos
Autores principales: Sánchez-Blázquez, Pilar, Rodríguez-Muñoz, María, Garzón, Javier
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890584/
https://www.ncbi.nlm.nih.gov/pubmed/20585660
http://dx.doi.org/10.1371/journal.pone.0011278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890584/
https://www.ncbi.nlm.nih.gov/pubmed/20585660
http://dx.doi.org/10.1371/journal.pone.0011278

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