Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

BACKGROUND: Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivity towards DNA interstrand-crosslinking (ICL)-agents, F...

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Detalles Bibliográficos
Autores principales: Palagyi, Andreas, Neveling, Kornelia, Plinninger, Ursula, Ziesch, Andreas, Targosz, Bianca-Sabrina, Denk, Gerald U, Ochs, Stephanie, Rizzani, Antonia, Meier, Daniel, Thasler, Wolfgang E, Hanenberg, Helmut, De Toni, Enrico N, Bassermann, Florian, Schäfer, Claus, Göke, Burkhard, Schindler, Detlev, Gallmeier, Eike
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890608/
https://www.ncbi.nlm.nih.gov/pubmed/20509860
http://dx.doi.org/10.1186/1476-4598-9-127

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