Quantification of global myocardial oxygenation in humans: initial experience

PURPOSE: To assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO(2)) at rest and during pharmacologically-induced vasodilation in normal volunteers. METHODS: A breath-hold T(2 )quantification method is developed to calculate oxygen extraction fraction (OEF) and MVO(2 )rate at rest and/or during hyperemia, using a two-compartment model. A previously reported T(2 )quantification method using turbo-spin-echo sequence was also applied for comparison. CMR scans were performed in 6 normal volunteers. Each imaging session consisted of imaging at rest and during adenosine-induced vasodilation. The new T(2 )quantification method was applied to calculate T(2 )in the coronary sinus (CS), as well as in myocardial tissue. Resting CS OEF, representing resting global myocardial OEF, and myocardial OEF during adenosine vasodilation were then calculated by the model. Myocardial blood flow (MBF) was also obtained to calculate MVO(2), by using a first-pass perfusion imaging approach. RESULTS: The T(2 )quantification method yielded a hyperemic OEF of 0.37 ± 0.05 and a hyperemic MVO(2 )of 9.2 ± 2.4 μmol/g/min. The corresponding resting values were 0.73 ± 0.05 and 5.2 ± 1.7 μmol/g/min respectively, which agreed well with published literature values. The MVO(2 )rose proportionally with rate-pressure product from the rest condition. The T(2 )sensitivity is approximately 95% higher with the new T(2 )method than turbo-spin-echo method. CONCLUSION: The CMR oxygenation method demonstrates the potential for non-invasive estimation of myocardial oxygenation, and should be explored in patients with altered myocardial oxygenation.