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Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea

In 2009, infection with the liver fluke Clonorchis sinensis (C. sinensis) was classified as "carcinogenic to humans" (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive e...

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Autores principales: Shin, Hai-Rim, Oh, Jin-Kyoung, Lim, Min Kyung, Shin, Aesun, Kong, Hyun-Joo, Jung, Kyu-Won, Won, Young-Joo, Park, Sohee, Park, Sang-Jae, Hong, Sung-Tae
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890876/
https://www.ncbi.nlm.nih.gov/pubmed/20592891
http://dx.doi.org/10.3346/jkms.2010.25.7.1011
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author Shin, Hai-Rim
Oh, Jin-Kyoung
Lim, Min Kyung
Shin, Aesun
Kong, Hyun-Joo
Jung, Kyu-Won
Won, Young-Joo
Park, Sohee
Park, Sang-Jae
Hong, Sung-Tae
author_facet Shin, Hai-Rim
Oh, Jin-Kyoung
Lim, Min Kyung
Shin, Aesun
Kong, Hyun-Joo
Jung, Kyu-Won
Won, Young-Joo
Park, Sohee
Park, Sang-Jae
Hong, Sung-Tae
author_sort Shin, Hai-Rim
collection PubMed
description In 2009, infection with the liver fluke Clonorchis sinensis (C. sinensis) was classified as "carcinogenic to humans" (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive epidemiology of cholangiocarcinoma in Korea. We examined incidence trends of intrahepatic and extrahepatic cholangiocarcinomas, using data from the Korea National Cancer Incidence database for 1999-2005. The prevalence of C. sinensis infection was estimated from a recent population-based survey in rural endemic areas. Cholangiocarcinoma incidence rates are currently rising, even while primary liver cancer incidence rates are decreasing. Annual percent changes in cholangiocarcinoma incidence rates were 8% for males and 11% in females. Known areas of C. sinensis endemicity showed high incidence rates of cholangiocarcinoma. The positivity of C. sinensis eggs in stool samples from endemic areas was more than 25% of adults tested during 2005-2008. From a meta-analysis, the summary odds ratio for cholangiocarcinoma due to C. sinensis infection was 4.7 (95% confidence interval: 2.2-9.8). Approximately 10% of cholangiocarcinomas in Korea were caused by chronic C. sinensis infections. More specific policies, including health education and an extensive effort for early detection in endemic areas, are needed.
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spelling pubmed-28908762010-07-01 Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea Shin, Hai-Rim Oh, Jin-Kyoung Lim, Min Kyung Shin, Aesun Kong, Hyun-Joo Jung, Kyu-Won Won, Young-Joo Park, Sohee Park, Sang-Jae Hong, Sung-Tae J Korean Med Sci Original Article In 2009, infection with the liver fluke Clonorchis sinensis (C. sinensis) was classified as "carcinogenic to humans" (Group 1) based on its involvement in the etiology of cholangiocarcinoma by the International Agency for Research on Cancer. However, little is known about the descriptive epidemiology of cholangiocarcinoma in Korea. We examined incidence trends of intrahepatic and extrahepatic cholangiocarcinomas, using data from the Korea National Cancer Incidence database for 1999-2005. The prevalence of C. sinensis infection was estimated from a recent population-based survey in rural endemic areas. Cholangiocarcinoma incidence rates are currently rising, even while primary liver cancer incidence rates are decreasing. Annual percent changes in cholangiocarcinoma incidence rates were 8% for males and 11% in females. Known areas of C. sinensis endemicity showed high incidence rates of cholangiocarcinoma. The positivity of C. sinensis eggs in stool samples from endemic areas was more than 25% of adults tested during 2005-2008. From a meta-analysis, the summary odds ratio for cholangiocarcinoma due to C. sinensis infection was 4.7 (95% confidence interval: 2.2-9.8). Approximately 10% of cholangiocarcinomas in Korea were caused by chronic C. sinensis infections. More specific policies, including health education and an extensive effort for early detection in endemic areas, are needed. The Korean Academy of Medical Sciences 2010-07 2010-06-17 /pmc/articles/PMC2890876/ /pubmed/20592891 http://dx.doi.org/10.3346/jkms.2010.25.7.1011 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Hai-Rim
Oh, Jin-Kyoung
Lim, Min Kyung
Shin, Aesun
Kong, Hyun-Joo
Jung, Kyu-Won
Won, Young-Joo
Park, Sohee
Park, Sang-Jae
Hong, Sung-Tae
Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title_full Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title_fullStr Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title_full_unstemmed Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title_short Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea
title_sort descriptive epidemiology of cholangiocarcinoma and clonorchiasis in korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890876/
https://www.ncbi.nlm.nih.gov/pubmed/20592891
http://dx.doi.org/10.3346/jkms.2010.25.7.1011
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