Cargando…

Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats

This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no signif...

Descripción completa

Detalles Bibliográficos
Autores principales: Chun, Mu-Ryun, Lee, Youn Ju, Kim, Ki-Hoon, Kim, Yong-Woon, Park, So-Young, Lee, Keun-Mi, Kim, Jong-Yeon, Park, Yoon-Ki
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890883/
https://www.ncbi.nlm.nih.gov/pubmed/20592898
http://dx.doi.org/10.3346/jkms.2010.25.7.1053
_version_ 1782182846610276352
author Chun, Mu-Ryun
Lee, Youn Ju
Kim, Ki-Hoon
Kim, Yong-Woon
Park, So-Young
Lee, Keun-Mi
Kim, Jong-Yeon
Park, Yoon-Ki
author_facet Chun, Mu-Ryun
Lee, Youn Ju
Kim, Ki-Hoon
Kim, Yong-Woon
Park, So-Young
Lee, Keun-Mi
Kim, Jong-Yeon
Park, Yoon-Ki
author_sort Chun, Mu-Ryun
collection PubMed
description This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no significant differences among groups. Calorie intake in both high-sucrose and high-starch diet groups was higher than in chow group. The high-fat high-sucrose diet induced decrease in insulin-stimulated glucose transport was partially improved by supplement with fish oil. Calorie intake in high-fat high-sucrose and fish oil supplemented groups was higher than in chow group. The decreased insulin-stimulated glucose transport was accompanied by the increase in visceral fat mass, plasma triglyceride and insulin levels. These changes were improved by the supplement with fish oil. These results demonstrate that the composition of fat in diet is clearly instrumental in the induction of muscle insulin resistance. However, in high carbohydrate diet, it is likely that the amount of calorie intake may be a more important factor in causing insulin resistance than the composition of carbohydrate. Thus, the compositions of carbohydrate and fat in diet differentially affect on muscle insulin resistance.
format Text
id pubmed-2890883
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-28908832010-07-01 Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats Chun, Mu-Ryun Lee, Youn Ju Kim, Ki-Hoon Kim, Yong-Woon Park, So-Young Lee, Keun-Mi Kim, Jong-Yeon Park, Yoon-Ki J Korean Med Sci Original Article This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no significant differences among groups. Calorie intake in both high-sucrose and high-starch diet groups was higher than in chow group. The high-fat high-sucrose diet induced decrease in insulin-stimulated glucose transport was partially improved by supplement with fish oil. Calorie intake in high-fat high-sucrose and fish oil supplemented groups was higher than in chow group. The decreased insulin-stimulated glucose transport was accompanied by the increase in visceral fat mass, plasma triglyceride and insulin levels. These changes were improved by the supplement with fish oil. These results demonstrate that the composition of fat in diet is clearly instrumental in the induction of muscle insulin resistance. However, in high carbohydrate diet, it is likely that the amount of calorie intake may be a more important factor in causing insulin resistance than the composition of carbohydrate. Thus, the compositions of carbohydrate and fat in diet differentially affect on muscle insulin resistance. The Korean Academy of Medical Sciences 2010-07 2010-06-17 /pmc/articles/PMC2890883/ /pubmed/20592898 http://dx.doi.org/10.3346/jkms.2010.25.7.1053 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chun, Mu-Ryun
Lee, Youn Ju
Kim, Ki-Hoon
Kim, Yong-Woon
Park, So-Young
Lee, Keun-Mi
Kim, Jong-Yeon
Park, Yoon-Ki
Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title_full Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title_fullStr Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title_full_unstemmed Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title_short Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats
title_sort differential effects of high-carbohydrate and high-fat diet composition on muscle insulin resistance in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890883/
https://www.ncbi.nlm.nih.gov/pubmed/20592898
http://dx.doi.org/10.3346/jkms.2010.25.7.1053
work_keys_str_mv AT chunmuryun differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT leeyounju differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT kimkihoon differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT kimyongwoon differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT parksoyoung differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT leekeunmi differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT kimjongyeon differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats
AT parkyoonki differentialeffectsofhighcarbohydrateandhighfatdietcompositiononmuscleinsulinresistanceinrats