Cargando…

Fertility preservation in young cancer patients

As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibil...

Descripción completa

Detalles Bibliográficos
Autores principales: Revel, Ariel, Revel-Vilk, Shoshana
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890901/
https://www.ncbi.nlm.nih.gov/pubmed/20607000
http://dx.doi.org/10.4103/0974-1208.63113
_version_ 1782182850968158208
author Revel, Ariel
Revel-Vilk, Shoshana
author_facet Revel, Ariel
Revel-Vilk, Shoshana
author_sort Revel, Ariel
collection PubMed
description As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibility for future fertility. Currently established methods for the preservation of fertility are available only for pubertal males and females. Pubertal male cancer patients should be encouraged to freeze numerous sperm samples even when sperm count and motility are poor. In these cases, intracytoplasmic sperm injection is a powerful technique compared with intrauterine insemination since thawed sperm samples with poor parameters can produce relatively high fertilization rates resulting in normal pregnancies and deliveries. Married pubertal women should be proposed ovulation induction, follicular aspiration, and fertilization with husband sperm. Single women could benefit from vitrification of oocytes. This requires a delay of about 3 weeks in the commencement of chemotherapy to enable follicular growth. Fertility preservation for prepubertal patients is more of a problem. Young girls could be offered cryopreservation of gametes in the gonadal tissue. Cryopreservation of testicular tissue was suggested for fertility preservation for young boys, but this method is totally experimental and not currently offered. Discussing future fertility is part of the consultation of young female and male patients facing potentially gonadotoxic cancer therapy. It is the role of reproductive specialists to create various options in their laboratory to preserve fertility potential of cancer patients.
format Text
id pubmed-2890901
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-28909012010-07-06 Fertility preservation in young cancer patients Revel, Ariel Revel-Vilk, Shoshana J Hum Reprod Sci Review Article As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibility for future fertility. Currently established methods for the preservation of fertility are available only for pubertal males and females. Pubertal male cancer patients should be encouraged to freeze numerous sperm samples even when sperm count and motility are poor. In these cases, intracytoplasmic sperm injection is a powerful technique compared with intrauterine insemination since thawed sperm samples with poor parameters can produce relatively high fertilization rates resulting in normal pregnancies and deliveries. Married pubertal women should be proposed ovulation induction, follicular aspiration, and fertilization with husband sperm. Single women could benefit from vitrification of oocytes. This requires a delay of about 3 weeks in the commencement of chemotherapy to enable follicular growth. Fertility preservation for prepubertal patients is more of a problem. Young girls could be offered cryopreservation of gametes in the gonadal tissue. Cryopreservation of testicular tissue was suggested for fertility preservation for young boys, but this method is totally experimental and not currently offered. Discussing future fertility is part of the consultation of young female and male patients facing potentially gonadotoxic cancer therapy. It is the role of reproductive specialists to create various options in their laboratory to preserve fertility potential of cancer patients. Medknow Publications 2010 /pmc/articles/PMC2890901/ /pubmed/20607000 http://dx.doi.org/10.4103/0974-1208.63113 Text en © Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Revel, Ariel
Revel-Vilk, Shoshana
Fertility preservation in young cancer patients
title Fertility preservation in young cancer patients
title_full Fertility preservation in young cancer patients
title_fullStr Fertility preservation in young cancer patients
title_full_unstemmed Fertility preservation in young cancer patients
title_short Fertility preservation in young cancer patients
title_sort fertility preservation in young cancer patients
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890901/
https://www.ncbi.nlm.nih.gov/pubmed/20607000
http://dx.doi.org/10.4103/0974-1208.63113
work_keys_str_mv AT revelariel fertilitypreservationinyoungcancerpatients
AT revelvilkshoshana fertilitypreservationinyoungcancerpatients