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Fertility preservation in young cancer patients
As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibil...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890901/ https://www.ncbi.nlm.nih.gov/pubmed/20607000 http://dx.doi.org/10.4103/0974-1208.63113 |
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author | Revel, Ariel Revel-Vilk, Shoshana |
author_facet | Revel, Ariel Revel-Vilk, Shoshana |
author_sort | Revel, Ariel |
collection | PubMed |
description | As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibility for future fertility. Currently established methods for the preservation of fertility are available only for pubertal males and females. Pubertal male cancer patients should be encouraged to freeze numerous sperm samples even when sperm count and motility are poor. In these cases, intracytoplasmic sperm injection is a powerful technique compared with intrauterine insemination since thawed sperm samples with poor parameters can produce relatively high fertilization rates resulting in normal pregnancies and deliveries. Married pubertal women should be proposed ovulation induction, follicular aspiration, and fertilization with husband sperm. Single women could benefit from vitrification of oocytes. This requires a delay of about 3 weeks in the commencement of chemotherapy to enable follicular growth. Fertility preservation for prepubertal patients is more of a problem. Young girls could be offered cryopreservation of gametes in the gonadal tissue. Cryopreservation of testicular tissue was suggested for fertility preservation for young boys, but this method is totally experimental and not currently offered. Discussing future fertility is part of the consultation of young female and male patients facing potentially gonadotoxic cancer therapy. It is the role of reproductive specialists to create various options in their laboratory to preserve fertility potential of cancer patients. |
format | Text |
id | pubmed-2890901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28909012010-07-06 Fertility preservation in young cancer patients Revel, Ariel Revel-Vilk, Shoshana J Hum Reprod Sci Review Article As a result of advances in treatment, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. The increased survival rate of children and adolescents with cancer has resulted in a major interest in the long-term effects of cancer treatment on the possibility for future fertility. Currently established methods for the preservation of fertility are available only for pubertal males and females. Pubertal male cancer patients should be encouraged to freeze numerous sperm samples even when sperm count and motility are poor. In these cases, intracytoplasmic sperm injection is a powerful technique compared with intrauterine insemination since thawed sperm samples with poor parameters can produce relatively high fertilization rates resulting in normal pregnancies and deliveries. Married pubertal women should be proposed ovulation induction, follicular aspiration, and fertilization with husband sperm. Single women could benefit from vitrification of oocytes. This requires a delay of about 3 weeks in the commencement of chemotherapy to enable follicular growth. Fertility preservation for prepubertal patients is more of a problem. Young girls could be offered cryopreservation of gametes in the gonadal tissue. Cryopreservation of testicular tissue was suggested for fertility preservation for young boys, but this method is totally experimental and not currently offered. Discussing future fertility is part of the consultation of young female and male patients facing potentially gonadotoxic cancer therapy. It is the role of reproductive specialists to create various options in their laboratory to preserve fertility potential of cancer patients. Medknow Publications 2010 /pmc/articles/PMC2890901/ /pubmed/20607000 http://dx.doi.org/10.4103/0974-1208.63113 Text en © Journal of Human Reproductive Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Revel, Ariel Revel-Vilk, Shoshana Fertility preservation in young cancer patients |
title | Fertility preservation in young cancer patients |
title_full | Fertility preservation in young cancer patients |
title_fullStr | Fertility preservation in young cancer patients |
title_full_unstemmed | Fertility preservation in young cancer patients |
title_short | Fertility preservation in young cancer patients |
title_sort | fertility preservation in young cancer patients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890901/ https://www.ncbi.nlm.nih.gov/pubmed/20607000 http://dx.doi.org/10.4103/0974-1208.63113 |
work_keys_str_mv | AT revelariel fertilitypreservationinyoungcancerpatients AT revelvilkshoshana fertilitypreservationinyoungcancerpatients |