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Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5m genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,4...
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891673/ https://www.ncbi.nlm.nih.gov/pubmed/19430483 http://dx.doi.org/10.1038/ng.361 |
| _version_ | 1782182882908831744 |
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| author | Newton-Cheh, Christopher Johnson, Toby Gateva, Vesela Tobin, Martin D Bochud, Murielle Coin, Lachlan Najjar, Samer S Zhao, Jing Hua Heath, Simon C Eyheramendy, Susana Papadakis, Konstantinos Voight, Benjamin F Scott, Laura J Zhang, Feng Farrall, Martin Tanaka, Toshiko Wallace, Chris Chambers, John C Khaw, Kay-Tee Nilsson, Peter van der Harst, Pim Polidoro, Silvia Grobbee, Diederick E Onland-Moret, N Charlotte Bots, Michiel L Wain, Louise V Elliott, Katherine S Teumer, Alexander Luan, Jian’an Lucas, Gavin Kuusisto, Johanna Burton, Paul R Hadley, David McArdle, Wendy L Brown, Morris Dominiczak, Anna Newhouse, Stephen J Samani, Nilesh J Webster, John Zeggini, Eleftheria Beckmann, Jacques S Bergmann, Sven Lim, Noha Song, Kijoung Vollenweider, Peter Waeber, Gerard Waterworth, Dawn M Yuan, Xin Groop, Leif Orho-Melander, Marju Allione, Alessandra Di Gregorio, Alessandra Guarrera, Simonetta Panico, Salvatore Ricceri, Fulvio Romanazzi, Valeria Sacerdote, Carlotta Vineis, Paolo Barroso, Inês Sandhu, Manjinder S Luben, Robert N Crawford, Gabriel J. Jousilahti, Pekka Perola, Markus Boehnke, Michael Bonnycastle, Lori L Collins, Francis S Jackson, Anne U Mohlke, Karen L Stringham, Heather M Valle, Timo T Willer, Cristen J Bergman, Richard N Morken, Mario A Döring, Angela Gieger, Christian Illig, Thomas Meitinger, Thomas Org, Elin Pfeufer, Arne Wichmann, H Erich Kathiresan, Sekar Marrugat, Jaume O’Donnell, Christopher J Schwartz, Stephen M Siscovick, David S Subirana, Isaac Freimer, Nelson B Hartikainen, Anna-Liisa McCarthy, Mark I O’Reilly, Paul F Peltonen, Leena Pouta, Anneli de Jong, Paul E Snieder, Harold van Gilst, Wiek H Clarke, Robert Goel, Anuj Hamsten, Anders Peden, John F Seedorf, Udo Syvänen, Ann-Christine Tognoni, Giovanni Lakatta, Edward G Sanna, Serena Scheet, Paul Schlessinger, David Scuteri, Angelo Dörr, Marcus Ernst, Florian Felix, Stephan B Homuth, Georg Lorbeer, Roberto Reffelmann, Thorsten Rettig, Rainer Völker, Uwe Galan, Pilar Gut, Ivo G Hercberg, Serge Lathrop, G Mark Zeleneka, Diana Deloukas, Panos Soranzo, Nicole Williams, Frances M Zhai, Guangju Salomaa, Veikko Laakso, Markku Elosua, Roberto Forouhi, Nita G Völzke, Henry Uiterwaal, Cuno S van der Schouw, Yvonne T Numans, Mattijs E Matullo, Giuseppe Navis, Gerjan Berglund, Göran Bingham, Sheila A Kooner, Jaspal S Paterson, Andrew D Connell, John M Bandinelli, Stefania Ferrucci, Luigi Watkins, Hugh Spector, Tim D Tuomilehto, Jaakko Altshuler, David Strachan, David P Laan, Maris Meneton, Pierre Wareham, Nicholas J Uda, Manuela Jarvelin, Marjo-Riitta Mooser, Vincent Melander, Olle Loos, Ruth JF Elliott, Paul Abecasis, Goncalo R Caulfield, Mark Munroe, Patricia B |
| author_facet | Newton-Cheh, Christopher Johnson, Toby Gateva, Vesela Tobin, Martin D Bochud, Murielle Coin, Lachlan Najjar, Samer S Zhao, Jing Hua Heath, Simon C Eyheramendy, Susana Papadakis, Konstantinos Voight, Benjamin F Scott, Laura J Zhang, Feng Farrall, Martin Tanaka, Toshiko Wallace, Chris Chambers, John C Khaw, Kay-Tee Nilsson, Peter van der Harst, Pim Polidoro, Silvia Grobbee, Diederick E Onland-Moret, N Charlotte Bots, Michiel L Wain, Louise V Elliott, Katherine S Teumer, Alexander Luan, Jian’an Lucas, Gavin Kuusisto, Johanna Burton, Paul R Hadley, David McArdle, Wendy L Brown, Morris Dominiczak, Anna Newhouse, Stephen J Samani, Nilesh J Webster, John Zeggini, Eleftheria Beckmann, Jacques S Bergmann, Sven Lim, Noha Song, Kijoung Vollenweider, Peter Waeber, Gerard Waterworth, Dawn M Yuan, Xin Groop, Leif Orho-Melander, Marju Allione, Alessandra Di Gregorio, Alessandra Guarrera, Simonetta Panico, Salvatore Ricceri, Fulvio Romanazzi, Valeria Sacerdote, Carlotta Vineis, Paolo Barroso, Inês Sandhu, Manjinder S Luben, Robert N Crawford, Gabriel J. Jousilahti, Pekka Perola, Markus Boehnke, Michael Bonnycastle, Lori L Collins, Francis S Jackson, Anne U Mohlke, Karen L Stringham, Heather M Valle, Timo T Willer, Cristen J Bergman, Richard N Morken, Mario A Döring, Angela Gieger, Christian Illig, Thomas Meitinger, Thomas Org, Elin Pfeufer, Arne Wichmann, H Erich Kathiresan, Sekar Marrugat, Jaume O’Donnell, Christopher J Schwartz, Stephen M Siscovick, David S Subirana, Isaac Freimer, Nelson B Hartikainen, Anna-Liisa McCarthy, Mark I O’Reilly, Paul F Peltonen, Leena Pouta, Anneli de Jong, Paul E Snieder, Harold van Gilst, Wiek H Clarke, Robert Goel, Anuj Hamsten, Anders Peden, John F Seedorf, Udo Syvänen, Ann-Christine Tognoni, Giovanni Lakatta, Edward G Sanna, Serena Scheet, Paul Schlessinger, David Scuteri, Angelo Dörr, Marcus Ernst, Florian Felix, Stephan B Homuth, Georg Lorbeer, Roberto Reffelmann, Thorsten Rettig, Rainer Völker, Uwe Galan, Pilar Gut, Ivo G Hercberg, Serge Lathrop, G Mark Zeleneka, Diana Deloukas, Panos Soranzo, Nicole Williams, Frances M Zhai, Guangju Salomaa, Veikko Laakso, Markku Elosua, Roberto Forouhi, Nita G Völzke, Henry Uiterwaal, Cuno S van der Schouw, Yvonne T Numans, Mattijs E Matullo, Giuseppe Navis, Gerjan Berglund, Göran Bingham, Sheila A Kooner, Jaspal S Paterson, Andrew D Connell, John M Bandinelli, Stefania Ferrucci, Luigi Watkins, Hugh Spector, Tim D Tuomilehto, Jaakko Altshuler, David Strachan, David P Laan, Maris Meneton, Pierre Wareham, Nicholas J Uda, Manuela Jarvelin, Marjo-Riitta Mooser, Vincent Melander, Olle Loos, Ruth JF Elliott, Paul Abecasis, Goncalo R Caulfield, Mark Munroe, Patricia B |
| author_sort | Newton-Cheh, Christopher |
| collection | PubMed |
| description | Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5m genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N≤71,225 European ancestry, N=12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N=29,136). We identified association between systolic or diastolic blood pressure and common variants in 8 regions near the CYP17A1 (P=7×10(−24)), CYP1A2 (P=1×10(−23)), FGF5 (P=1×10(−21)), SH2B3 (P=3×10(−18)), MTHFR (P=2×10(−13)), c10orf107 (P=1×10(−9)), ZNF652 (P=5×10(−9)) and PLCD3 (P=1×10(−8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. |
| format | Text |
| id | pubmed-2891673 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28916732010-09-21 Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry Newton-Cheh, Christopher Johnson, Toby Gateva, Vesela Tobin, Martin D Bochud, Murielle Coin, Lachlan Najjar, Samer S Zhao, Jing Hua Heath, Simon C Eyheramendy, Susana Papadakis, Konstantinos Voight, Benjamin F Scott, Laura J Zhang, Feng Farrall, Martin Tanaka, Toshiko Wallace, Chris Chambers, John C Khaw, Kay-Tee Nilsson, Peter van der Harst, Pim Polidoro, Silvia Grobbee, Diederick E Onland-Moret, N Charlotte Bots, Michiel L Wain, Louise V Elliott, Katherine S Teumer, Alexander Luan, Jian’an Lucas, Gavin Kuusisto, Johanna Burton, Paul R Hadley, David McArdle, Wendy L Brown, Morris Dominiczak, Anna Newhouse, Stephen J Samani, Nilesh J Webster, John Zeggini, Eleftheria Beckmann, Jacques S Bergmann, Sven Lim, Noha Song, Kijoung Vollenweider, Peter Waeber, Gerard Waterworth, Dawn M Yuan, Xin Groop, Leif Orho-Melander, Marju Allione, Alessandra Di Gregorio, Alessandra Guarrera, Simonetta Panico, Salvatore Ricceri, Fulvio Romanazzi, Valeria Sacerdote, Carlotta Vineis, Paolo Barroso, Inês Sandhu, Manjinder S Luben, Robert N Crawford, Gabriel J. Jousilahti, Pekka Perola, Markus Boehnke, Michael Bonnycastle, Lori L Collins, Francis S Jackson, Anne U Mohlke, Karen L Stringham, Heather M Valle, Timo T Willer, Cristen J Bergman, Richard N Morken, Mario A Döring, Angela Gieger, Christian Illig, Thomas Meitinger, Thomas Org, Elin Pfeufer, Arne Wichmann, H Erich Kathiresan, Sekar Marrugat, Jaume O’Donnell, Christopher J Schwartz, Stephen M Siscovick, David S Subirana, Isaac Freimer, Nelson B Hartikainen, Anna-Liisa McCarthy, Mark I O’Reilly, Paul F Peltonen, Leena Pouta, Anneli de Jong, Paul E Snieder, Harold van Gilst, Wiek H Clarke, Robert Goel, Anuj Hamsten, Anders Peden, John F Seedorf, Udo Syvänen, Ann-Christine Tognoni, Giovanni Lakatta, Edward G Sanna, Serena Scheet, Paul Schlessinger, David Scuteri, Angelo Dörr, Marcus Ernst, Florian Felix, Stephan B Homuth, Georg Lorbeer, Roberto Reffelmann, Thorsten Rettig, Rainer Völker, Uwe Galan, Pilar Gut, Ivo G Hercberg, Serge Lathrop, G Mark Zeleneka, Diana Deloukas, Panos Soranzo, Nicole Williams, Frances M Zhai, Guangju Salomaa, Veikko Laakso, Markku Elosua, Roberto Forouhi, Nita G Völzke, Henry Uiterwaal, Cuno S van der Schouw, Yvonne T Numans, Mattijs E Matullo, Giuseppe Navis, Gerjan Berglund, Göran Bingham, Sheila A Kooner, Jaspal S Paterson, Andrew D Connell, John M Bandinelli, Stefania Ferrucci, Luigi Watkins, Hugh Spector, Tim D Tuomilehto, Jaakko Altshuler, David Strachan, David P Laan, Maris Meneton, Pierre Wareham, Nicholas J Uda, Manuela Jarvelin, Marjo-Riitta Mooser, Vincent Melander, Olle Loos, Ruth JF Elliott, Paul Abecasis, Goncalo R Caulfield, Mark Munroe, Patricia B Nat Genet Article Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5m genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N≤71,225 European ancestry, N=12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N=29,136). We identified association between systolic or diastolic blood pressure and common variants in 8 regions near the CYP17A1 (P=7×10(−24)), CYP1A2 (P=1×10(−23)), FGF5 (P=1×10(−21)), SH2B3 (P=3×10(−18)), MTHFR (P=2×10(−13)), c10orf107 (P=1×10(−9)), ZNF652 (P=5×10(−9)) and PLCD3 (P=1×10(−8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease. 2009-05-10 2009-06 /pmc/articles/PMC2891673/ /pubmed/19430483 http://dx.doi.org/10.1038/ng.361 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Newton-Cheh, Christopher Johnson, Toby Gateva, Vesela Tobin, Martin D Bochud, Murielle Coin, Lachlan Najjar, Samer S Zhao, Jing Hua Heath, Simon C Eyheramendy, Susana Papadakis, Konstantinos Voight, Benjamin F Scott, Laura J Zhang, Feng Farrall, Martin Tanaka, Toshiko Wallace, Chris Chambers, John C Khaw, Kay-Tee Nilsson, Peter van der Harst, Pim Polidoro, Silvia Grobbee, Diederick E Onland-Moret, N Charlotte Bots, Michiel L Wain, Louise V Elliott, Katherine S Teumer, Alexander Luan, Jian’an Lucas, Gavin Kuusisto, Johanna Burton, Paul R Hadley, David McArdle, Wendy L Brown, Morris Dominiczak, Anna Newhouse, Stephen J Samani, Nilesh J Webster, John Zeggini, Eleftheria Beckmann, Jacques S Bergmann, Sven Lim, Noha Song, Kijoung Vollenweider, Peter Waeber, Gerard Waterworth, Dawn M Yuan, Xin Groop, Leif Orho-Melander, Marju Allione, Alessandra Di Gregorio, Alessandra Guarrera, Simonetta Panico, Salvatore Ricceri, Fulvio Romanazzi, Valeria Sacerdote, Carlotta Vineis, Paolo Barroso, Inês Sandhu, Manjinder S Luben, Robert N Crawford, Gabriel J. Jousilahti, Pekka Perola, Markus Boehnke, Michael Bonnycastle, Lori L Collins, Francis S Jackson, Anne U Mohlke, Karen L Stringham, Heather M Valle, Timo T Willer, Cristen J Bergman, Richard N Morken, Mario A Döring, Angela Gieger, Christian Illig, Thomas Meitinger, Thomas Org, Elin Pfeufer, Arne Wichmann, H Erich Kathiresan, Sekar Marrugat, Jaume O’Donnell, Christopher J Schwartz, Stephen M Siscovick, David S Subirana, Isaac Freimer, Nelson B Hartikainen, Anna-Liisa McCarthy, Mark I O’Reilly, Paul F Peltonen, Leena Pouta, Anneli de Jong, Paul E Snieder, Harold van Gilst, Wiek H Clarke, Robert Goel, Anuj Hamsten, Anders Peden, John F Seedorf, Udo Syvänen, Ann-Christine Tognoni, Giovanni Lakatta, Edward G Sanna, Serena Scheet, Paul Schlessinger, David Scuteri, Angelo Dörr, Marcus Ernst, Florian Felix, Stephan B Homuth, Georg Lorbeer, Roberto Reffelmann, Thorsten Rettig, Rainer Völker, Uwe Galan, Pilar Gut, Ivo G Hercberg, Serge Lathrop, G Mark Zeleneka, Diana Deloukas, Panos Soranzo, Nicole Williams, Frances M Zhai, Guangju Salomaa, Veikko Laakso, Markku Elosua, Roberto Forouhi, Nita G Völzke, Henry Uiterwaal, Cuno S van der Schouw, Yvonne T Numans, Mattijs E Matullo, Giuseppe Navis, Gerjan Berglund, Göran Bingham, Sheila A Kooner, Jaspal S Paterson, Andrew D Connell, John M Bandinelli, Stefania Ferrucci, Luigi Watkins, Hugh Spector, Tim D Tuomilehto, Jaakko Altshuler, David Strachan, David P Laan, Maris Meneton, Pierre Wareham, Nicholas J Uda, Manuela Jarvelin, Marjo-Riitta Mooser, Vincent Melander, Olle Loos, Ruth JF Elliott, Paul Abecasis, Goncalo R Caulfield, Mark Munroe, Patricia B Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title | Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title_full | Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title_fullStr | Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title_full_unstemmed | Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title_short | Eight blood pressure loci identified by genome-wide association study of 34,433 people of European ancestry |
| title_sort | eight blood pressure loci identified by genome-wide association study of 34,433 people of european ancestry |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891673/ https://www.ncbi.nlm.nih.gov/pubmed/19430483 http://dx.doi.org/10.1038/ng.361 |
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