Cargando…

A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis

The original concept of asthma being primarily a disease of airways smooth muscle drove the development of bronchodilator drugs. However when it was realised that airway inflammation underpinned the disordered airway function, this gave way to the development of controller therapies such as inhaled...

Descripción completa

Detalles Bibliográficos
Autor principal: Holgate, Stephen T
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892047/
https://www.ncbi.nlm.nih.gov/pubmed/20592914
http://dx.doi.org/10.4168/aair.2010.2.3.165
_version_ 1782182915716677632
author Holgate, Stephen T
author_facet Holgate, Stephen T
author_sort Holgate, Stephen T
collection PubMed
description The original concept of asthma being primarily a disease of airways smooth muscle drove the development of bronchodilator drugs. However when it was realised that airway inflammation underpinned the disordered airway function, this gave way to the development of controller therapies such as inhaled cromones and corticosteroids. More recently the discovery of complex interconnecting cytokine and chemokine networks has stimulated the development of biologics with varying success. With the recognition that airway wall "remodelling" is present early in asthma inception and is in part driven by aberrant epithelial-mesenchymal communication both genetic and environmental factors beyond allergen exposure such as virus infection and air pollution are being seen as being increasingly important not only in asthma exacerbations but in the origins of asthma and its evolution into different sub-phenotypes. This brings us round full circle to once again considering that the origins of asthma lie in defects in the formed elements of the airway; the epithelium, smooth muscle, and vasculature. Over the last 25 years Professor You Young Kim has engaged in the exciting discovery science of allergy and asthma and has made an enormous contribution in bringing Korea to the forefront of disease management and research, a position that both he and his colleagues can justly be proud of.
format Text
id pubmed-2892047
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
record_format MEDLINE/PubMed
spelling pubmed-28920472010-07-01 A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis Holgate, Stephen T Allergy Asthma Immunol Res Review The original concept of asthma being primarily a disease of airways smooth muscle drove the development of bronchodilator drugs. However when it was realised that airway inflammation underpinned the disordered airway function, this gave way to the development of controller therapies such as inhaled cromones and corticosteroids. More recently the discovery of complex interconnecting cytokine and chemokine networks has stimulated the development of biologics with varying success. With the recognition that airway wall "remodelling" is present early in asthma inception and is in part driven by aberrant epithelial-mesenchymal communication both genetic and environmental factors beyond allergen exposure such as virus infection and air pollution are being seen as being increasingly important not only in asthma exacerbations but in the origins of asthma and its evolution into different sub-phenotypes. This brings us round full circle to once again considering that the origins of asthma lie in defects in the formed elements of the airway; the epithelium, smooth muscle, and vasculature. Over the last 25 years Professor You Young Kim has engaged in the exciting discovery science of allergy and asthma and has made an enormous contribution in bringing Korea to the forefront of disease management and research, a position that both he and his colleagues can justly be proud of. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010-07 2010-05-06 /pmc/articles/PMC2892047/ /pubmed/20592914 http://dx.doi.org/10.4168/aair.2010.2.3.165 Text en Copyright © 2010 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Holgate, Stephen T
A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title_full A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title_fullStr A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title_full_unstemmed A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title_short A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
title_sort brief history of asthma and its mechanisms to modern concepts of disease pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892047/
https://www.ncbi.nlm.nih.gov/pubmed/20592914
http://dx.doi.org/10.4168/aair.2010.2.3.165
work_keys_str_mv AT holgatestephent abriefhistoryofasthmaanditsmechanismstomodernconceptsofdiseasepathogenesis
AT holgatestephent briefhistoryofasthmaanditsmechanismstomodernconceptsofdiseasepathogenesis