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Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors

BACKGROUND: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with global DNA methylation status. LINE-1 hypomethylation in colon cancer has been...

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Detalles Bibliográficos
Autores principales:	Baba, Yoshifumi, Huttenhower, Curtis, Nosho, Katsuhiko, Tanaka, Noriko, Shima, Kaori, Hazra, Aditi, Schernhammer, Eva S, Hunter, David J, Giovannucci, Edward L, Fuchs, Charles S, Ogino, Shuji
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892454/ https://www.ncbi.nlm.nih.gov/pubmed/20507599 http://dx.doi.org/10.1186/1476-4598-9-125

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