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Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulati...

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Autores principales: Abnet, Christian C., Chen, Yu, Chow, Wong-Ho, Gao, Yu-Tang, Helzlsouer, Kathy J., Le Marchand, Loïc, McCullough, Marjorie L., Shikany, James M., Virtamo, Jarmo, Weinstein, Stephanie J., Xiang, Yong-Bing, Yu, Kai, Zheng, Wei, Albanes, Demetrius, Arslan, Alan A., Campbell, David S., Campbell, Peter T., Hayes, Richard B., Horst, Ronald L., Kolonel, Laurence N., Nomura, Abraham M. Y., Purdue, Mark P., Snyder, Kirk, Shu, Xiao-Ou
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892544/
https://www.ncbi.nlm.nih.gov/pubmed/20562192
http://dx.doi.org/10.1093/aje/kwq121
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author Abnet, Christian C.
Chen, Yu
Chow, Wong-Ho
Gao, Yu-Tang
Helzlsouer, Kathy J.
Le Marchand, Loïc
McCullough, Marjorie L.
Shikany, James M.
Virtamo, Jarmo
Weinstein, Stephanie J.
Xiang, Yong-Bing
Yu, Kai
Zheng, Wei
Albanes, Demetrius
Arslan, Alan A.
Campbell, David S.
Campbell, Peter T.
Hayes, Richard B.
Horst, Ronald L.
Kolonel, Laurence N.
Nomura, Abraham M. Y.
Purdue, Mark P.
Snyder, Kirk
Shu, Xiao-Ou
author_facet Abnet, Christian C.
Chen, Yu
Chow, Wong-Ho
Gao, Yu-Tang
Helzlsouer, Kathy J.
Le Marchand, Loïc
McCullough, Marjorie L.
Shikany, James M.
Virtamo, Jarmo
Weinstein, Stephanie J.
Xiang, Yong-Bing
Yu, Kai
Zheng, Wei
Albanes, Demetrius
Arslan, Alan A.
Campbell, David S.
Campbell, Peter T.
Hayes, Richard B.
Horst, Ronald L.
Kolonel, Laurence N.
Nomura, Abraham M. Y.
Purdue, Mark P.
Snyder, Kirk
Shu, Xiao-Ou
author_sort Abnet, Christian C.
collection PubMed
description Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw–matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50–<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers.
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spelling pubmed-28925442010-06-28 Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers Abnet, Christian C. Chen, Yu Chow, Wong-Ho Gao, Yu-Tang Helzlsouer, Kathy J. Le Marchand, Loïc McCullough, Marjorie L. Shikany, James M. Virtamo, Jarmo Weinstein, Stephanie J. Xiang, Yong-Bing Yu, Kai Zheng, Wei Albanes, Demetrius Arslan, Alan A. Campbell, David S. Campbell, Peter T. Hayes, Richard B. Horst, Ronald L. Kolonel, Laurence N. Nomura, Abraham M. Y. Purdue, Mark P. Snyder, Kirk Shu, Xiao-Ou Am J Epidemiol Original Contributions Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw–matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D (<25 nmol/L) were associated with a statistically significant decreased risk of upper GI cancer (reference: 50–<75 nmol/L) (odds ratio = 0.53, 95% confidence interval: 0.31, 0.91; P trend = 0.003). Never smokers with concentrations of <25 nmol/L showed a lower risk of upper GI cancers (odds ratio = 0.55, 95% confidence interval: 0.31, 0.96). Subgroup analyses by alcohol consumption produced opposing trends. Results do not support the hypothesis that interventions aimed at increasing vitamin D status would lead to a lower risk of these highly fatal cancers. Oxford University Press 2010-07-01 2010-06-18 /pmc/articles/PMC2892544/ /pubmed/20562192 http://dx.doi.org/10.1093/aje/kwq121 Text en American Journal of Epidemiology Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2010. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
Abnet, Christian C.
Chen, Yu
Chow, Wong-Ho
Gao, Yu-Tang
Helzlsouer, Kathy J.
Le Marchand, Loïc
McCullough, Marjorie L.
Shikany, James M.
Virtamo, Jarmo
Weinstein, Stephanie J.
Xiang, Yong-Bing
Yu, Kai
Zheng, Wei
Albanes, Demetrius
Arslan, Alan A.
Campbell, David S.
Campbell, Peter T.
Hayes, Richard B.
Horst, Ronald L.
Kolonel, Laurence N.
Nomura, Abraham M. Y.
Purdue, Mark P.
Snyder, Kirk
Shu, Xiao-Ou
Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title_full Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title_fullStr Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title_full_unstemmed Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title_short Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
title_sort circulating 25-hydroxyvitamin d and risk of esophageal and gastric cancer: cohort consortium vitamin d pooling project of rarer cancers
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892544/
https://www.ncbi.nlm.nih.gov/pubmed/20562192
http://dx.doi.org/10.1093/aje/kwq121
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