Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy

BACKGROUND: We evaluated the effect and safety of the immediate postoperative continuous infusion of remifentanil at two doses in patients undergoing laparoscopic-assisted vaginal hysterectomy (LAVH) with alfentanil-based patient-controlled analgesia (PCA). METHODS: The study enrolled 50 ASA physica...

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Autores principales: Lee, Jae Jun, Hwang, Sung Mi, Lee, Jun Sung, Hong, Sung Jun, Lee, Soo Kyung, Lim, So Young
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892587/
https://www.ncbi.nlm.nih.gov/pubmed/20589178
http://dx.doi.org/10.4097/kjae.2010.58.6.537
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author Lee, Jae Jun
Hwang, Sung Mi
Lee, Jun Sung
Hong, Sung Jun
Lee, Soo Kyung
Lim, So Young
author_facet Lee, Jae Jun
Hwang, Sung Mi
Lee, Jun Sung
Hong, Sung Jun
Lee, Soo Kyung
Lim, So Young
author_sort Lee, Jae Jun
collection PubMed
description BACKGROUND: We evaluated the effect and safety of the immediate postoperative continuous infusion of remifentanil at two doses in patients undergoing laparoscopic-assisted vaginal hysterectomy (LAVH) with alfentanil-based patient-controlled analgesia (PCA). METHODS: The study enrolled 50 ASA physical status 1 or 2 patients scheduled to undergo LAVH. Anesthesia was maintained with sevoflurane-remifentanil-air. At the last skin suture, the sevoflurane was discontinued, and patients were randomized to receive remifentanil 0.05 µg/kg/min (group I) or 0.1 µg/kg/min (group II). PCA was started at the time of eye opening and response to a verbal command. In the recovery room, we monitored the mean arterial blood pressure (MAP), heart rate (HR), respiratory rate (RR), SpO(2), and bispectral index (BIS) at 5-minute intervals. Thirty minutes after starting PCA, the remifentanil was discontinued. Pain was assessed using a visual analog scale (0 = no pain; 100 = the worst possible pain) at 0, 5, 10, and 30 minutes after stopping the remifentanil infusion. RESULTS: The eye opening time, BIS, MAP, and HR did not differ significantly between the two groups, and pain scores were similar between the two groups. Respiratory depression (SpO(2) < 90% or RR < 8/min) did not occur in group I but did occur in three patients in group II. CONCLUSIONS: Continuous remifentanil infusion (0.05 µg/kg/min) immediately postoperatively with alfentanil-based PCA had a similar effect as a 0.1 µg/kg/min infusion with respect to pain control without side effects. However, special attention must be given to respiratory depression.
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spelling pubmed-28925872010-06-29 Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy Lee, Jae Jun Hwang, Sung Mi Lee, Jun Sung Hong, Sung Jun Lee, Soo Kyung Lim, So Young Korean J Anesthesiol Clinical Research Article BACKGROUND: We evaluated the effect and safety of the immediate postoperative continuous infusion of remifentanil at two doses in patients undergoing laparoscopic-assisted vaginal hysterectomy (LAVH) with alfentanil-based patient-controlled analgesia (PCA). METHODS: The study enrolled 50 ASA physical status 1 or 2 patients scheduled to undergo LAVH. Anesthesia was maintained with sevoflurane-remifentanil-air. At the last skin suture, the sevoflurane was discontinued, and patients were randomized to receive remifentanil 0.05 µg/kg/min (group I) or 0.1 µg/kg/min (group II). PCA was started at the time of eye opening and response to a verbal command. In the recovery room, we monitored the mean arterial blood pressure (MAP), heart rate (HR), respiratory rate (RR), SpO(2), and bispectral index (BIS) at 5-minute intervals. Thirty minutes after starting PCA, the remifentanil was discontinued. Pain was assessed using a visual analog scale (0 = no pain; 100 = the worst possible pain) at 0, 5, 10, and 30 minutes after stopping the remifentanil infusion. RESULTS: The eye opening time, BIS, MAP, and HR did not differ significantly between the two groups, and pain scores were similar between the two groups. Respiratory depression (SpO(2) < 90% or RR < 8/min) did not occur in group I but did occur in three patients in group II. CONCLUSIONS: Continuous remifentanil infusion (0.05 µg/kg/min) immediately postoperatively with alfentanil-based PCA had a similar effect as a 0.1 µg/kg/min infusion with respect to pain control without side effects. However, special attention must be given to respiratory depression. The Korean Society of Anesthesiologists 2010-06 2010-06-23 /pmc/articles/PMC2892587/ /pubmed/20589178 http://dx.doi.org/10.4097/kjae.2010.58.6.537 Text en Copyright © The Korean Society of Anesthesiologists, 2010 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Lee, Jae Jun
Hwang, Sung Mi
Lee, Jun Sung
Hong, Sung Jun
Lee, Soo Kyung
Lim, So Young
Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title_full Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title_fullStr Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title_full_unstemmed Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title_short Continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
title_sort continuous infusion of two doses of remifentanil immediately after laparoscopic-assisted vaginal hysterectomy
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892587/
https://www.ncbi.nlm.nih.gov/pubmed/20589178
http://dx.doi.org/10.4097/kjae.2010.58.6.537
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