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Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bo...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892651/ https://www.ncbi.nlm.nih.gov/pubmed/20589083 http://dx.doi.org/10.1155/2010/161454 |
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author | Bandara, Mahesh Seder, David B. Garratty, George Leger, Regina M. Zuckerman, Jonathan B. |
author_facet | Bandara, Mahesh Seder, David B. Garratty, George Leger, Regina M. Zuckerman, Jonathan B. |
author_sort | Bandara, Mahesh |
collection | PubMed |
description | We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF. |
format | Text |
id | pubmed-2892651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28926512010-06-29 Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis Bandara, Mahesh Seder, David B. Garratty, George Leger, Regina M. Zuckerman, Jonathan B. Case Rep Med Case Report We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF. Hindawi Publishing Corporation 2010 2010-06-02 /pmc/articles/PMC2892651/ /pubmed/20589083 http://dx.doi.org/10.1155/2010/161454 Text en Copyright © 2010 Mahesh Bandara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bandara, Mahesh Seder, David B. Garratty, George Leger, Regina M. Zuckerman, Jonathan B. Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title_full | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title_fullStr | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title_full_unstemmed | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title_short | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
title_sort | piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892651/ https://www.ncbi.nlm.nih.gov/pubmed/20589083 http://dx.doi.org/10.1155/2010/161454 |
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