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Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis

We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bo...

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Autores principales: Bandara, Mahesh, Seder, David B., Garratty, George, Leger, Regina M., Zuckerman, Jonathan B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892651/
https://www.ncbi.nlm.nih.gov/pubmed/20589083
http://dx.doi.org/10.1155/2010/161454
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author Bandara, Mahesh
Seder, David B.
Garratty, George
Leger, Regina M.
Zuckerman, Jonathan B.
author_facet Bandara, Mahesh
Seder, David B.
Garratty, George
Leger, Regina M.
Zuckerman, Jonathan B.
author_sort Bandara, Mahesh
collection PubMed
description We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF.
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spelling pubmed-28926512010-06-29 Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis Bandara, Mahesh Seder, David B. Garratty, George Leger, Regina M. Zuckerman, Jonathan B. Case Rep Med Case Report We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF. Hindawi Publishing Corporation 2010 2010-06-02 /pmc/articles/PMC2892651/ /pubmed/20589083 http://dx.doi.org/10.1155/2010/161454 Text en Copyright © 2010 Mahesh Bandara et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bandara, Mahesh
Seder, David B.
Garratty, George
Leger, Regina M.
Zuckerman, Jonathan B.
Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title_full Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title_fullStr Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title_full_unstemmed Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title_short Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
title_sort piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892651/
https://www.ncbi.nlm.nih.gov/pubmed/20589083
http://dx.doi.org/10.1155/2010/161454
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