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Cerebral Venous Sinus (Sinovenous) Thrombosis in Children

Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associ...

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Detalles Bibliográficos
Autores principales: Dlamini, Nomazulu, Billinghurst, Lori, Kirkham, Fenella J.
Formato: Texto
Lenguaje:English
Publicado: W.B. Saunders 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892748/
https://www.ncbi.nlm.nih.gov/pubmed/20561500
http://dx.doi.org/10.1016/j.nec.2010.03.006
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author Dlamini, Nomazulu
Billinghurst, Lori
Kirkham, Fenella J.
author_facet Dlamini, Nomazulu
Billinghurst, Lori
Kirkham, Fenella J.
author_sort Dlamini, Nomazulu
collection PubMed
description Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associated with neonatal CSVT. Although there is considerable overlap in risk factors for CSVT in neonates and older infants and children, specific differences exist between the groups. Clinical symptoms are frequently nonspecific, which may obscure the diagnosis and delay treatment. While morbidity and mortality are significant, CSVT recurs less commonly than arterial ischemic stroke in children. Appropriate management may reduce the risk of recurrence and improve outcome, however there are no randomized controlled trials to support the use of anticoagulation in children. Although commonly employed in many centers, this practice remains controversial, highlighting the continued need for high-quality studies. This article reviews the literature pertaining to pediatric venous sinus thrombosis.
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spelling pubmed-28927482010-07-23 Cerebral Venous Sinus (Sinovenous) Thrombosis in Children Dlamini, Nomazulu Billinghurst, Lori Kirkham, Fenella J. Neurosurg Clin N Am Article Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associated with neonatal CSVT. Although there is considerable overlap in risk factors for CSVT in neonates and older infants and children, specific differences exist between the groups. Clinical symptoms are frequently nonspecific, which may obscure the diagnosis and delay treatment. While morbidity and mortality are significant, CSVT recurs less commonly than arterial ischemic stroke in children. Appropriate management may reduce the risk of recurrence and improve outcome, however there are no randomized controlled trials to support the use of anticoagulation in children. Although commonly employed in many centers, this practice remains controversial, highlighting the continued need for high-quality studies. This article reviews the literature pertaining to pediatric venous sinus thrombosis. W.B. Saunders 2010-07 /pmc/articles/PMC2892748/ /pubmed/20561500 http://dx.doi.org/10.1016/j.nec.2010.03.006 Text en © 2010 Elsevier Inc. https://creativecommons.org/licenses/by/4.0/ Open Access under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) license
spellingShingle Article
Dlamini, Nomazulu
Billinghurst, Lori
Kirkham, Fenella J.
Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title_full Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title_fullStr Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title_full_unstemmed Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title_short Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
title_sort cerebral venous sinus (sinovenous) thrombosis in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892748/
https://www.ncbi.nlm.nih.gov/pubmed/20561500
http://dx.doi.org/10.1016/j.nec.2010.03.006
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