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Cerebral Venous Sinus (Sinovenous) Thrombosis in Children
Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associ...
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Formato: | Texto |
Lenguaje: | English |
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W.B. Saunders
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892748/ https://www.ncbi.nlm.nih.gov/pubmed/20561500 http://dx.doi.org/10.1016/j.nec.2010.03.006 |
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author | Dlamini, Nomazulu Billinghurst, Lori Kirkham, Fenella J. |
author_facet | Dlamini, Nomazulu Billinghurst, Lori Kirkham, Fenella J. |
author_sort | Dlamini, Nomazulu |
collection | PubMed |
description | Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associated with neonatal CSVT. Although there is considerable overlap in risk factors for CSVT in neonates and older infants and children, specific differences exist between the groups. Clinical symptoms are frequently nonspecific, which may obscure the diagnosis and delay treatment. While morbidity and mortality are significant, CSVT recurs less commonly than arterial ischemic stroke in children. Appropriate management may reduce the risk of recurrence and improve outcome, however there are no randomized controlled trials to support the use of anticoagulation in children. Although commonly employed in many centers, this practice remains controversial, highlighting the continued need for high-quality studies. This article reviews the literature pertaining to pediatric venous sinus thrombosis. |
format | Text |
id | pubmed-2892748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | W.B. Saunders |
record_format | MEDLINE/PubMed |
spelling | pubmed-28927482010-07-23 Cerebral Venous Sinus (Sinovenous) Thrombosis in Children Dlamini, Nomazulu Billinghurst, Lori Kirkham, Fenella J. Neurosurg Clin N Am Article Cerebral venous sinus (sinovenous) thrombosis (CSVT) in childhood is a rare, but underrecognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%. There is an expanding spectrum of perinatal brain injury associated with neonatal CSVT. Although there is considerable overlap in risk factors for CSVT in neonates and older infants and children, specific differences exist between the groups. Clinical symptoms are frequently nonspecific, which may obscure the diagnosis and delay treatment. While morbidity and mortality are significant, CSVT recurs less commonly than arterial ischemic stroke in children. Appropriate management may reduce the risk of recurrence and improve outcome, however there are no randomized controlled trials to support the use of anticoagulation in children. Although commonly employed in many centers, this practice remains controversial, highlighting the continued need for high-quality studies. This article reviews the literature pertaining to pediatric venous sinus thrombosis. W.B. Saunders 2010-07 /pmc/articles/PMC2892748/ /pubmed/20561500 http://dx.doi.org/10.1016/j.nec.2010.03.006 Text en © 2010 Elsevier Inc. https://creativecommons.org/licenses/by/4.0/ Open Access under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) license |
spellingShingle | Article Dlamini, Nomazulu Billinghurst, Lori Kirkham, Fenella J. Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title | Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title_full | Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title_fullStr | Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title_full_unstemmed | Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title_short | Cerebral Venous Sinus (Sinovenous) Thrombosis in Children |
title_sort | cerebral venous sinus (sinovenous) thrombosis in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892748/ https://www.ncbi.nlm.nih.gov/pubmed/20561500 http://dx.doi.org/10.1016/j.nec.2010.03.006 |
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