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Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies

Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p...

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Detalles Bibliográficos
Autores principales: Yu, Jing, Bhargava, Rohit, Dabbs, David J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893118/
https://www.ncbi.nlm.nih.gov/pubmed/20550696
http://dx.doi.org/10.1186/1746-1596-5-36
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author Yu, Jing
Bhargava, Rohit
Dabbs, David J
author_facet Yu, Jing
Bhargava, Rohit
Dabbs, David J
author_sort Yu, Jing
collection PubMed
description Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed ductal-like cytoplasmic MUC1 staining, but were negative for MUC2 and other mucin gene markers. In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm. The findings suggest that the presence of extracellular mucin does not exclude a diagnosis of lobular carcinoma, and the morphologic and molecular characteristics of lobular and ductal carcinomas are more complex than previously appreciated.
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spelling pubmed-28931182010-06-29 Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies Yu, Jing Bhargava, Rohit Dabbs, David J Diagn Pathol Case Report Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed ductal-like cytoplasmic MUC1 staining, but were negative for MUC2 and other mucin gene markers. In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm. The findings suggest that the presence of extracellular mucin does not exclude a diagnosis of lobular carcinoma, and the morphologic and molecular characteristics of lobular and ductal carcinomas are more complex than previously appreciated. BioMed Central 2010-06-15 /pmc/articles/PMC2893118/ /pubmed/20550696 http://dx.doi.org/10.1186/1746-1596-5-36 Text en Copyright ©2010 Yu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yu, Jing
Bhargava, Rohit
Dabbs, David J
Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title_full Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title_fullStr Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title_full_unstemmed Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title_short Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies
title_sort invasive lobular carcinoma with extracellular mucin production and her-2 overexpression: a case report and further case studies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893118/
https://www.ncbi.nlm.nih.gov/pubmed/20550696
http://dx.doi.org/10.1186/1746-1596-5-36
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