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Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study

AIM: Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endoth...

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Autores principales: Kveiborg, Britt, Hermann, Thomas S, Major-Pedersen, Atheline, Christiansen, Buris, Rask-Madsen, Christian, Raunsø, Jakob, Køber, Lars, Torp-Pedersen, Christian, Dominguez, Helena
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893119/
https://www.ncbi.nlm.nih.gov/pubmed/20500877
http://dx.doi.org/10.1186/1475-2840-9-21
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author Kveiborg, Britt
Hermann, Thomas S
Major-Pedersen, Atheline
Christiansen, Buris
Rask-Madsen, Christian
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
author_facet Kveiborg, Britt
Hermann, Thomas S
Major-Pedersen, Atheline
Christiansen, Buris
Rask-Madsen, Christian
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
author_sort Kveiborg, Britt
collection PubMed
description AIM: Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endothelial function in patients with type 2 diabetes. METHOD: 24 patients with type 2 diabetes were randomized to receive either 200 mg metoprolol succinate or 50 mg carvedilol daily. Endothelium-dependent vasodilation was assessed by using venous occlusion plethysmography with increasing doses of intra-arterial infusions of the agonist serotonin. Insulin-stimulated endothelial function was assessed after co-infusion of insulin for sixty minutes. Vaso-reactivity studies were done before and after the two-month treatment period. RESULTS: Insulin-stimulated endothelial function was deteriorated after treatment with metoprolol, the percentage change in forearm blood-flow was 60.19% ± 17.89 (at the highest serotonin dosages) before treatment and -33.80% ± 23.38 after treatment (p = 0.007). Treatment with carvedilol did not change insulin-stimulated endothelial function. Endothelium-dependent vasodilation without insulin was not changed in either of the two treatment groups. CONCLUSION: This study shows that vascular insulin sensitivity was preserved during treatment with carvedilol while blunted during treatment with metoprolol in patients with type 2 diabetes. TRIAL REGISTRATION: Current Controlled Trials NCT00497003
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spelling pubmed-28931192010-06-29 Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study Kveiborg, Britt Hermann, Thomas S Major-Pedersen, Atheline Christiansen, Buris Rask-Madsen, Christian Raunsø, Jakob Køber, Lars Torp-Pedersen, Christian Dominguez, Helena Cardiovasc Diabetol Original investigation AIM: Studies of beta blockade in patients with type 2 diabetes have shown inferiority of metoprolol treatment compared to carvedilol on indices of insulin resistance. The aim of this study was to examine the effect of metoprolol versus carvedilol on endothelial function and insulin-stimulated endothelial function in patients with type 2 diabetes. METHOD: 24 patients with type 2 diabetes were randomized to receive either 200 mg metoprolol succinate or 50 mg carvedilol daily. Endothelium-dependent vasodilation was assessed by using venous occlusion plethysmography with increasing doses of intra-arterial infusions of the agonist serotonin. Insulin-stimulated endothelial function was assessed after co-infusion of insulin for sixty minutes. Vaso-reactivity studies were done before and after the two-month treatment period. RESULTS: Insulin-stimulated endothelial function was deteriorated after treatment with metoprolol, the percentage change in forearm blood-flow was 60.19% ± 17.89 (at the highest serotonin dosages) before treatment and -33.80% ± 23.38 after treatment (p = 0.007). Treatment with carvedilol did not change insulin-stimulated endothelial function. Endothelium-dependent vasodilation without insulin was not changed in either of the two treatment groups. CONCLUSION: This study shows that vascular insulin sensitivity was preserved during treatment with carvedilol while blunted during treatment with metoprolol in patients with type 2 diabetes. TRIAL REGISTRATION: Current Controlled Trials NCT00497003 BioMed Central 2010-05-25 /pmc/articles/PMC2893119/ /pubmed/20500877 http://dx.doi.org/10.1186/1475-2840-9-21 Text en Copyright ©2010 Kveiborg et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original investigation
Kveiborg, Britt
Hermann, Thomas S
Major-Pedersen, Atheline
Christiansen, Buris
Rask-Madsen, Christian
Raunsø, Jakob
Køber, Lars
Torp-Pedersen, Christian
Dominguez, Helena
Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title_full Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title_fullStr Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title_full_unstemmed Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title_short Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
title_sort metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study
topic Original investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893119/
https://www.ncbi.nlm.nih.gov/pubmed/20500877
http://dx.doi.org/10.1186/1475-2840-9-21
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