Common variants in FOXP1 are associated with generalized vitiligo

In a recent genome-wide association study of generalized vitiligo (GV) we identified 10 confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of GV w...

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Detalles Bibliográficos
Autores principales: Jin, Ying, Birlea, Stanca A., Fain, Pamela R., Mailloux, Christina M., Riccardi, Sheri L., Gowan, Katherine, Holland, Paulene J., Bennett, Dorothy C., Wallace, Margaret R., McCormack, Wayne T., Kemp, E. Helen, Gawkrodger, David J., Weetman, Anthony P., Picardo, Mauro, Leone, Giovanni, Taïeb, Alain, Jouary, Thomas, Ezzedine, Khaled, van Geel, Nanny, Lambert, Jo, Overbeck, Andreas, Spritz, Richard A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893242/
https://www.ncbi.nlm.nih.gov/pubmed/20526340
http://dx.doi.org/10.1038/ng.602
Descripción
Sumario:In a recent genome-wide association study of generalized vitiligo (GV) we identified 10 confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of GV with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10(-7)).

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