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Common variants in FOXP1 are associated with generalized vitiligo
In a recent genome-wide association study of generalized vitiligo (GV) we identified 10 confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of GV w...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893242/ https://www.ncbi.nlm.nih.gov/pubmed/20526340 http://dx.doi.org/10.1038/ng.602 |
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| author | Jin, Ying Birlea, Stanca A. Fain, Pamela R. Mailloux, Christina M. Riccardi, Sheri L. Gowan, Katherine Holland, Paulene J. Bennett, Dorothy C. Wallace, Margaret R. McCormack, Wayne T. Kemp, E. Helen Gawkrodger, David J. Weetman, Anthony P. Picardo, Mauro Leone, Giovanni Taïeb, Alain Jouary, Thomas Ezzedine, Khaled van Geel, Nanny Lambert, Jo Overbeck, Andreas Spritz, Richard A. |
| author_facet | Jin, Ying Birlea, Stanca A. Fain, Pamela R. Mailloux, Christina M. Riccardi, Sheri L. Gowan, Katherine Holland, Paulene J. Bennett, Dorothy C. Wallace, Margaret R. McCormack, Wayne T. Kemp, E. Helen Gawkrodger, David J. Weetman, Anthony P. Picardo, Mauro Leone, Giovanni Taïeb, Alain Jouary, Thomas Ezzedine, Khaled van Geel, Nanny Lambert, Jo Overbeck, Andreas Spritz, Richard A. |
| author_sort | Jin, Ying |
| collection | PubMed |
| description | In a recent genome-wide association study of generalized vitiligo (GV) we identified 10 confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of GV with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10(-7)). |
| format | Text |
| id | pubmed-2893242 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28932422011-01-01 Common variants in FOXP1 are associated with generalized vitiligo Jin, Ying Birlea, Stanca A. Fain, Pamela R. Mailloux, Christina M. Riccardi, Sheri L. Gowan, Katherine Holland, Paulene J. Bennett, Dorothy C. Wallace, Margaret R. McCormack, Wayne T. Kemp, E. Helen Gawkrodger, David J. Weetman, Anthony P. Picardo, Mauro Leone, Giovanni Taïeb, Alain Jouary, Thomas Ezzedine, Khaled van Geel, Nanny Lambert, Jo Overbeck, Andreas Spritz, Richard A. Nat Genet Article In a recent genome-wide association study of generalized vitiligo (GV) we identified 10 confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of GV with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10(-7)). 2010-06-06 2010-07 /pmc/articles/PMC2893242/ /pubmed/20526340 http://dx.doi.org/10.1038/ng.602 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Jin, Ying Birlea, Stanca A. Fain, Pamela R. Mailloux, Christina M. Riccardi, Sheri L. Gowan, Katherine Holland, Paulene J. Bennett, Dorothy C. Wallace, Margaret R. McCormack, Wayne T. Kemp, E. Helen Gawkrodger, David J. Weetman, Anthony P. Picardo, Mauro Leone, Giovanni Taïeb, Alain Jouary, Thomas Ezzedine, Khaled van Geel, Nanny Lambert, Jo Overbeck, Andreas Spritz, Richard A. Common variants in FOXP1 are associated with generalized vitiligo |
| title | Common variants in FOXP1 are associated with generalized vitiligo |
| title_full | Common variants in FOXP1 are associated with generalized vitiligo |
| title_fullStr | Common variants in FOXP1 are associated with generalized vitiligo |
| title_full_unstemmed | Common variants in FOXP1 are associated with generalized vitiligo |
| title_short | Common variants in FOXP1 are associated with generalized vitiligo |
| title_sort | common variants in foxp1 are associated with generalized vitiligo |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893242/ https://www.ncbi.nlm.nih.gov/pubmed/20526340 http://dx.doi.org/10.1038/ng.602 |
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