Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

In humans, absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome (FXS), the most common inherited form of intellectual disability. Here we report through biochemical and electrophysiological studies that FMRP binds the C-terminus of the Slack s...

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Autores principales: Brown, Maile R., Kronengold, Jack, Gazula, Valeswara-Rao, Chen, Yi, Strumbos, John G., Sigworth, Fred J., Navaratnam, Dhasakumar, Kaczmarek, Leonard K.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893252/
https://www.ncbi.nlm.nih.gov/pubmed/20512134
http://dx.doi.org/10.1038/nn.2563
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author Brown, Maile R.
Kronengold, Jack
Gazula, Valeswara-Rao
Chen, Yi
Strumbos, John G.
Sigworth, Fred J.
Navaratnam, Dhasakumar
Kaczmarek, Leonard K.
author_facet Brown, Maile R.
Kronengold, Jack
Gazula, Valeswara-Rao
Chen, Yi
Strumbos, John G.
Sigworth, Fred J.
Navaratnam, Dhasakumar
Kaczmarek, Leonard K.
author_sort Brown, Maile R.
collection PubMed
description In humans, absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome (FXS), the most common inherited form of intellectual disability. Here we report through biochemical and electrophysiological studies that FMRP binds the C-terminus of the Slack sodium-activated potassium channel to activate the channel. The findings suggest that Slack activity may provide a link between patterns of neuronal firing and changes in protein translation.
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spelling pubmed-28932522011-01-01 Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack Brown, Maile R. Kronengold, Jack Gazula, Valeswara-Rao Chen, Yi Strumbos, John G. Sigworth, Fred J. Navaratnam, Dhasakumar Kaczmarek, Leonard K. Nat Neurosci Article In humans, absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome (FXS), the most common inherited form of intellectual disability. Here we report through biochemical and electrophysiological studies that FMRP binds the C-terminus of the Slack sodium-activated potassium channel to activate the channel. The findings suggest that Slack activity may provide a link between patterns of neuronal firing and changes in protein translation. 2010-05-30 2010-07 /pmc/articles/PMC2893252/ /pubmed/20512134 http://dx.doi.org/10.1038/nn.2563 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Brown, Maile R.
Kronengold, Jack
Gazula, Valeswara-Rao
Chen, Yi
Strumbos, John G.
Sigworth, Fred J.
Navaratnam, Dhasakumar
Kaczmarek, Leonard K.
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title_full Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title_fullStr Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title_full_unstemmed Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title_short Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
title_sort fragile x mental retardation protein controls gating of the sodium-activated potassium channel slack
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893252/
https://www.ncbi.nlm.nih.gov/pubmed/20512134
http://dx.doi.org/10.1038/nn.2563
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