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Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke

BACKGROUND AND OBJECTIVES: Carotid intima-media thickness (IMT) has been associated with an increased risk of ischemic stroke. To better understand this association, we evaluated the relationships of vascular risk factors, including carotid IMT and carotid plaque, and large territory cerebral infarc...

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Autores principales: Yoon, Hyun Ju, Jeong, Myung Ho, Kim, Kye Hun, Ahn, Younggeun, Cho, Jeong Gwan, Park, Jong Chun, Kang, Jung Chaee, Bae, Jang Ho
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893367/
https://www.ncbi.nlm.nih.gov/pubmed/20589199
http://dx.doi.org/10.4070/kcj.2010.40.6.272
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author Yoon, Hyun Ju
Jeong, Myung Ho
Kim, Kye Hun
Ahn, Younggeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
Bae, Jang Ho
author_facet Yoon, Hyun Ju
Jeong, Myung Ho
Kim, Kye Hun
Ahn, Younggeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
Bae, Jang Ho
author_sort Yoon, Hyun Ju
collection PubMed
description BACKGROUND AND OBJECTIVES: Carotid intima-media thickness (IMT) has been associated with an increased risk of ischemic stroke. To better understand this association, we evaluated the relationships of vascular risk factors, including carotid IMT and carotid plaque, and large territory cerebral infarction and small vessel stroke. SUBJECTS AND METHODS: A total of 502 patients with acute ischemic stroke were divided into two groups according to neurologic examinations and imaging studies; 1) a large territory infarction group (group I: n=126, 64.4±11 years, 78 males) and 2) a small vessel stroke group (group II: n=376, 62.5±11 years, 242 males). We evaluated associations between (a) territory and non-territory strokes and (b) age, sex, potential vascular risk factors, carotid image and cardiac function (by echocardiography). RESULTS: We did not find significant between group differences of age, sex, diabetes, previous history of ischemic stroke, plaque (presence, site and size of carotid plaque), and velocity of carotid blood flow and left ventricle ejection fraction. However, group I had a higher incidence of hypertension (p=0.006), smoking (p=0.003), and dyslipidemia (p=0.001). Group I had thicker carotid IMT than group II (right carotid: 0.81±0.21 mm vs. 0.76±0.19 mm, p=0.035; left carotid: 0.88±0.23 mm vs. 0.80±0.20 mm, p=0.014) and a higher e/e' level (12.08 vs. 9.66, p<0.001). Dyslipidemia, thicker carotid IMT and elevated E/E' ratios were significant independent predictors for large territory infarction in patients with ischemic stroke. CONCLUSION: Carotid IMT is significantly increased in patients with large territory infarction compared with those with small vessel stroke.
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spelling pubmed-28933672010-06-29 Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke Yoon, Hyun Ju Jeong, Myung Ho Kim, Kye Hun Ahn, Younggeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee Bae, Jang Ho Korean Circ J Original Article BACKGROUND AND OBJECTIVES: Carotid intima-media thickness (IMT) has been associated with an increased risk of ischemic stroke. To better understand this association, we evaluated the relationships of vascular risk factors, including carotid IMT and carotid plaque, and large territory cerebral infarction and small vessel stroke. SUBJECTS AND METHODS: A total of 502 patients with acute ischemic stroke were divided into two groups according to neurologic examinations and imaging studies; 1) a large territory infarction group (group I: n=126, 64.4±11 years, 78 males) and 2) a small vessel stroke group (group II: n=376, 62.5±11 years, 242 males). We evaluated associations between (a) territory and non-territory strokes and (b) age, sex, potential vascular risk factors, carotid image and cardiac function (by echocardiography). RESULTS: We did not find significant between group differences of age, sex, diabetes, previous history of ischemic stroke, plaque (presence, site and size of carotid plaque), and velocity of carotid blood flow and left ventricle ejection fraction. However, group I had a higher incidence of hypertension (p=0.006), smoking (p=0.003), and dyslipidemia (p=0.001). Group I had thicker carotid IMT than group II (right carotid: 0.81±0.21 mm vs. 0.76±0.19 mm, p=0.035; left carotid: 0.88±0.23 mm vs. 0.80±0.20 mm, p=0.014) and a higher e/e' level (12.08 vs. 9.66, p<0.001). Dyslipidemia, thicker carotid IMT and elevated E/E' ratios were significant independent predictors for large territory infarction in patients with ischemic stroke. CONCLUSION: Carotid IMT is significantly increased in patients with large territory infarction compared with those with small vessel stroke. The Korean Society of Cardiology 2010-06 2010-06-29 /pmc/articles/PMC2893367/ /pubmed/20589199 http://dx.doi.org/10.4070/kcj.2010.40.6.272 Text en Copyright © 2010 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoon, Hyun Ju
Jeong, Myung Ho
Kim, Kye Hun
Ahn, Younggeun
Cho, Jeong Gwan
Park, Jong Chun
Kang, Jung Chaee
Bae, Jang Ho
Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title_full Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title_fullStr Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title_full_unstemmed Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title_short Carotid Intima-Media Thickness, Not Carotid Plaque, is Associated With Large Territory Cerebral Infarction in Patients With Ischemic Stroke
title_sort carotid intima-media thickness, not carotid plaque, is associated with large territory cerebral infarction in patients with ischemic stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893367/
https://www.ncbi.nlm.nih.gov/pubmed/20589199
http://dx.doi.org/10.4070/kcj.2010.40.6.272
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