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The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

BACKGROUND: Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations including serious side effects and frequent emergence of intrinsic or acquired resistance. Thus, the novel platinum(IV) complex LA-12 represents a promising treatment modality,...

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Detalles Bibliográficos
Autores principales:	Kvardova, Veronika, Hrstka, Roman, Walerych, Dawid, Muller, Petr, Matoulkova, Eva, Hruskova, Veronika, Stelclova, Dagmar, Sova, Petr, Vojtesek, Borivoj
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893458/ https://www.ncbi.nlm.nih.gov/pubmed/20550649 http://dx.doi.org/10.1186/1476-4598-9-147

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