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Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?
BACKGROUND: To evaluate and compare the biological impact on different proposed margin recipes for the same geometric uncertainties for intra-hepatic tumors with different tumor cell types or clinical stages. METHOD: Three different margin recipes based on tumor motion were applied to sixteen IMRT p...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893459/ https://www.ncbi.nlm.nih.gov/pubmed/20525298 http://dx.doi.org/10.1186/1748-717X-5-48 |
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author | Kuo, Hsiang-Chi Liu, Wen-Shan Wu, Andrew Mah, Dennis Chuang, Keh-Shih Hong, Linda Yaparpalvi, Ravi Guha, Chandan Kalnicki, Shalom |
author_facet | Kuo, Hsiang-Chi Liu, Wen-Shan Wu, Andrew Mah, Dennis Chuang, Keh-Shih Hong, Linda Yaparpalvi, Ravi Guha, Chandan Kalnicki, Shalom |
author_sort | Kuo, Hsiang-Chi |
collection | PubMed |
description | BACKGROUND: To evaluate and compare the biological impact on different proposed margin recipes for the same geometric uncertainties for intra-hepatic tumors with different tumor cell types or clinical stages. METHOD: Three different margin recipes based on tumor motion were applied to sixteen IMRT plans with a total of twenty two intra-hepatic tumors. One recipe used the full amplitude of motion measured from patients to generate margins. A second used 70% of the full amplitude of motion, while the third had no margin for motion. The biological effects of geometric uncertainty in these three situations were evaluated with Equivalent Uniform Doses (EUD) for various survival fractions at 2 Gy (SF(2)). RESULTS: There was no significant difference in the biological impact between the full motion margin and the 70% motion margin. Also, there was no significant difference between different tumor cell types. When the margin for motion was eliminated, the difference of the biological impact was significant among different cell types due to geometric uncertainties. Elimination of the motion margin requires dose escalation to compensate for the biological dose reduction due to the geometric misses during treatment. CONCLUSIONS: Both patient-based margins of full motion and of 70% motion are sufficient to prevent serious dosimetric error. Clinical implementation of margin reduction should consider the tumor sensitivity to radiation. |
format | Text |
id | pubmed-2893459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28934592010-06-30 Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? Kuo, Hsiang-Chi Liu, Wen-Shan Wu, Andrew Mah, Dennis Chuang, Keh-Shih Hong, Linda Yaparpalvi, Ravi Guha, Chandan Kalnicki, Shalom Radiat Oncol Research BACKGROUND: To evaluate and compare the biological impact on different proposed margin recipes for the same geometric uncertainties for intra-hepatic tumors with different tumor cell types or clinical stages. METHOD: Three different margin recipes based on tumor motion were applied to sixteen IMRT plans with a total of twenty two intra-hepatic tumors. One recipe used the full amplitude of motion measured from patients to generate margins. A second used 70% of the full amplitude of motion, while the third had no margin for motion. The biological effects of geometric uncertainty in these three situations were evaluated with Equivalent Uniform Doses (EUD) for various survival fractions at 2 Gy (SF(2)). RESULTS: There was no significant difference in the biological impact between the full motion margin and the 70% motion margin. Also, there was no significant difference between different tumor cell types. When the margin for motion was eliminated, the difference of the biological impact was significant among different cell types due to geometric uncertainties. Elimination of the motion margin requires dose escalation to compensate for the biological dose reduction due to the geometric misses during treatment. CONCLUSIONS: Both patient-based margins of full motion and of 70% motion are sufficient to prevent serious dosimetric error. Clinical implementation of margin reduction should consider the tumor sensitivity to radiation. BioMed Central 2010-06-03 /pmc/articles/PMC2893459/ /pubmed/20525298 http://dx.doi.org/10.1186/1748-717X-5-48 Text en Copyright ©2010 Kuo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kuo, Hsiang-Chi Liu, Wen-Shan Wu, Andrew Mah, Dennis Chuang, Keh-Shih Hong, Linda Yaparpalvi, Ravi Guha, Chandan Kalnicki, Shalom Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title | Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title_full | Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title_fullStr | Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title_full_unstemmed | Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title_short | Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
title_sort | biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893459/ https://www.ncbi.nlm.nih.gov/pubmed/20525298 http://dx.doi.org/10.1186/1748-717X-5-48 |
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