Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation

The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Mea...

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Detalles Bibliográficos
Autores principales: Guo, Dadong, Wu, Chunhui, Li, Jingyuan, Guo, Airong, Li, Qingning, Jiang, Hui, Chen, Baoan, Wang, Xuemei
Formato: Texto
Lenguaje:English
Publicado: Springer 2009
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893715/
https://www.ncbi.nlm.nih.gov/pubmed/20651919
http://dx.doi.org/10.1007/s11671-009-9411-x
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author Guo, Dadong
Wu, Chunhui
Li, Jingyuan
Guo, Airong
Li, Qingning
Jiang, Hui
Chen, Baoan
Wang, Xuemei
author_facet Guo, Dadong
Wu, Chunhui
Li, Jingyuan
Guo, Airong
Li, Qingning
Jiang, Hui
Chen, Baoan
Wang, Xuemei
author_sort Guo, Dadong
collection PubMed
description The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.
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spelling pubmed-28937152010-07-21 Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation Guo, Dadong Wu, Chunhui Li, Jingyuan Guo, Airong Li, Qingning Jiang, Hui Chen, Baoan Wang, Xuemei Nanoscale Res Lett Nano Express The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells. Springer 2009-08-23 /pmc/articles/PMC2893715/ /pubmed/20651919 http://dx.doi.org/10.1007/s11671-009-9411-x Text en Copyright ©2009 to the authors
spellingShingle Nano Express
Guo, Dadong
Wu, Chunhui
Li, Jingyuan
Guo, Airong
Li, Qingning
Jiang, Hui
Chen, Baoan
Wang, Xuemei
Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title_full Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title_fullStr Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title_full_unstemmed Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title_short Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation
title_sort synergistic effect of functionalized nickel nanoparticles and quercetin on inhibition of the smmc-7721 cells proliferation
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893715/
https://www.ncbi.nlm.nih.gov/pubmed/20651919
http://dx.doi.org/10.1007/s11671-009-9411-x
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AT wangxuemei synergisticeffectoffunctionalizednickelnanoparticlesandquercetinoninhibitionofthesmmc7721cellsproliferation

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