Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on...

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Autores principales: Riggio, Cristina, Ciofani, Gianni, Raffa, Vittoria, Cuschieri, Alfred, Micera, Silvestro
Formato: Texto
Lenguaje:English
Publicado: Springer 2009
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893816/
https://www.ncbi.nlm.nih.gov/pubmed/20596464
http://dx.doi.org/10.1007/s11671-009-9291-0
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author Riggio, Cristina
Ciofani, Gianni
Raffa, Vittoria
Cuschieri, Alfred
Micera, Silvestro
author_facet Riggio, Cristina
Ciofani, Gianni
Raffa, Vittoria
Cuschieri, Alfred
Micera, Silvestro
author_sort Riggio, Cristina
collection PubMed
description In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.
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spelling pubmed-28938162010-06-30 Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level Riggio, Cristina Ciofani, Gianni Raffa, Vittoria Cuschieri, Alfred Micera, Silvestro Nanoscale Res Lett Nano Express In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform. Springer 2009-03-25 /pmc/articles/PMC2893816/ /pubmed/20596464 http://dx.doi.org/10.1007/s11671-009-9291-0 Text en Copyright © 2009 to the authors
spellingShingle Nano Express
Riggio, Cristina
Ciofani, Gianni
Raffa, Vittoria
Cuschieri, Alfred
Micera, Silvestro
Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title_full Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title_fullStr Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title_full_unstemmed Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title_short Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level
title_sort combination of polymer technology and carbon nanotube array for the development of an effective drug delivery system at cellular level
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893816/
https://www.ncbi.nlm.nih.gov/pubmed/20596464
http://dx.doi.org/10.1007/s11671-009-9291-0
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AT cuschierialfred combinationofpolymertechnologyandcarbonnanotubearrayforthedevelopmentofaneffectivedrugdeliverysystematcellularlevel
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