Fusel Alcohols Regulate Translation Initiation by Inhibiting eIF2B to Reduce Ternary Complex in a Mechanism That May Involve Altering the Integrity and Dynamics of the eIF2B Body

Recycling of eIF2-GDP to the GTP-bound form constitutes a core essential, regulated step in eukaryotic translation. This reaction is mediated by eIF2B, a heteropentameric factor with important links to human disease. eIF2 in the GTP-bound form binds to methionyl initiator tRNA to form a ternary comp...

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Detalles Bibliográficos
Autores principales: Taylor, Eleanor J., Campbell, Susan G., Griffiths, Christian D., Reid, Peter J., Slaven, John W., Harrison, Richard J., Sims, Paul F.G., Pavitt, Graham D., Delneri, Daniela, Ashe, Mark P.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893985/
https://www.ncbi.nlm.nih.gov/pubmed/20444979
http://dx.doi.org/10.1091/mbc.E09-11-0962

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