A Computational Approach for Identifying the Chemical Factors Involved in the Glycosaminoglycans-Mediated Acceleration of Amyloid Fibril Formation

BACKGROUND: Amyloid fibril formation is the hallmark of many human diseases, including Alzheimer's disease, type II diabetes and amyloidosis. Amyloid fibrils deposit in the extracellular space and generally co-localize with the glycosaminoglycans (GAGs) of the basement membrane. GAGs have been...

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Detalles Bibliográficos
Autores principales: Monsellier, Elodie, Ramazzotti, Matteo, Taddei, Niccolò, Chiti, Fabrizio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894048/
https://www.ncbi.nlm.nih.gov/pubmed/20613870
http://dx.doi.org/10.1371/journal.pone.0011363

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