Methylation of the Tumor Suppressor Protein, BRCA1, Influences Its Transcriptional Cofactor Function

BACKGROUND: Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling. This multifunctional nature of BRC...

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Detalles Bibliográficos
Autores principales: Guendel, Irene, Carpio, Lawrence, Pedati, Caitlin, Schwartz, Arnold, Teal, Christine, Kashanchi, Fatah, Kehn-Hall, Kylene
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894074/
https://www.ncbi.nlm.nih.gov/pubmed/20614009
http://dx.doi.org/10.1371/journal.pone.0011379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894074/
https://www.ncbi.nlm.nih.gov/pubmed/20614009
http://dx.doi.org/10.1371/journal.pone.0011379

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