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Methylation of the Tumor Suppressor Protein, BRCA1, Influences Its Transcriptional Cofactor Function
BACKGROUND: Approximately half of hereditary breast cancers have mutations in either BRCA1 or BRCA2. BRCA1 is a multifaceted tumor suppressor protein that has implications in processes such as cell cycle, transcription, DNA damage response and chromatin remodeling. This multifunctional nature of BRC...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894074/ https://www.ncbi.nlm.nih.gov/pubmed/20614009 http://dx.doi.org/10.1371/journal.pone.0011379 |